张广钦

发布者:基础医学发布时间:2016-03-13浏览次数:158

张广钦, 男,博士,副研究员,硕士生导师。

E-mail: njzhanggq@163.com

025-83271070 ()

  

受教育经历

2001/10-2003/10,北京大学,生命科学学院,博士后

1997/09-2001/06, 中国药科大学,药学院,博士

1989/09-1992/06,中国药科大学,药学院,硕士

1982/09-1985/06, 河南大学,药学系

研究工作经历

2009/10-2010/11,新加坡国家心脏中心,研究科学家

2005/01-2006/01,香港科技大学,生化系,博士后

2001/10-2003/10,北京大学,生命科学学院,博士后

2004/11-目前,中国药科大学,药学院,副研究员

1992/07-2001/09,中国药科大学,药学院,讲师

1985/8-1989/8,河南商丘地区中医院,药剂师

  

主要研究领域:

1.心肌和神经细胞离子通道研究以及细胞钙信号转导。

2.诱导性多潜能干细胞(iPS)定向心肌细胞分化的研究。

  

近几年发表的主要论文:

1.Zhang GQ, Wei H, Lu J, Wong P, Shim W. Identification and characterization of calcium sparks in cardiomyocytes derived from human induced pluripotent stem cells. PLoS One. 2013;8(2):e55266.

2.Wei H, Zhang G, Qiu S, Lu J, Sheng J, Manasi, Tan G, Wong P, Gan SU, Shim W.Hydrogen sulfide suppresses outward rectifier potassium currents in human pluripotent stem cell-derived cardiomyocytes. PLoS One. 2012;7(11):e50641.(并列作者).

3.Ma D, Wei H, Lu J, Ho S, Zhang G, Sun X, Oh Y, Tan SH, Ng ML, Shim W, Wong P, Liew R.Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy. Eur Heart J. 201334(15):1122-33..

4.Shim W, Mehta A, Lim SY, Zhang G, Lim CH, Chua T, Wong P.G-CSF for stem cell therapy in acute myocardial infarction: friend or foe? Cardiovasc Res. 2011;89(1):20-30.

5.Zhang GQ, Qiu SH, Wei HM.Scutellarin blocks sodium current in freshly isolated mouse hippocampal CA1 neurons. Neurochem Res. 2011, 36:947-54.

6.Zhang GQ, Wang H, Liu WT, Dong H, Fong WF, Tang LM, Xiong YH, Yu ZL, Ko KM.Long-Term Treatment with a Chinese Herbal Formula, Sheng-Mai-San, Improves Cardiac Contractile Function in Aged Rats: The Role of Ca2+ Homeostasis.Rejuvenation Res. 2008, 11: 991-1000.

7.Zhang GQ, Huang XD, Wang H, Leung AK, Chan CL, Fong DW, Yu ZL. Anti-inflammatory and analgesic effects of the ethanol extract of Rosa multiflora Thunb. hips. J Ethnopharmacol. 2008;118:290-4.

8.Fu Y, Zhang GQ, Hao XM, Wu CH, Chai Z, Wang SQ. Temperature dependence and thermodynamic properties of Ca2+ sparks in rat cardiomyocytes.Biophys J. 2005;89:2533-41

9.Zhang Guangqin, Fu Yu, Yang Dongmei, Hao Xuemei, Bai Shuhua, Tang Yiqun, Edward G Lakatta, Cheng Heping. Contribution of Spontaneous L-type Ca2+ channel activation to the genesis of Ca2+ sparks in resting cardiac myocyte. Science in China (C) 2004;47(1):31-8

10.ZHANG Guang-Qin, HAO Xue-Mei, DAI De-Zai, FU Yu, ZHOU Pei-Ai, WU Cai-Hong. Puerarin blocks Na+ current in isolated rat ventricular myocytes. Acta Pharmacol Sin 2003; 24(12): 1212-6

11.ZHANG Guang-Qin, HAO Xue-Mei, CHEN Shi-Zhong, ZHOU Pei-Ai, CHENG He-Ping, WU Cai-Hong. Blockade of paeoniflorin on sodium current in mouse hippocampal CA1 neurons. Acta Pharmacol Sin. 2003; 24(12):1248.-52

12.G-Q Zhang, X-M Hao, P-A Zhou, C-H Wu. Effect of paeonol on L-type calcium channel in rat ventricular myocytes. Mothods Find Exp Clin Pharmacol 2003; 25(4):281-5

13.ZHANG Guang-Qin, HAO Xue-Mei, ZHOU Pei-Ai, WU Cai-Hong, DAI De-Zai.Puerarin blocks transient outward K+ current and delayed rectifier K+ current in mice hippocampal CA1 neurons. Acta Pharmacol Sin 2001; 22(3):253-6.

14.Zou L.Y., Hao X.M., Zhang G.Q., Zhang M., Guo J.H., Liu T.F.: Effect of Tetramethyl Pyrazine on L-type Calcium Channel in Rat Ventricular Myocytes. Can. J. Physiol. Pharmacol 2001; 79: 621-6.

  

参与国家级科研项目:
 1
心律失常离子通道病变特征ERG基因表达及突变。国家自然科学基金资助项目。NO39870088
 2
改造槲皮素及葛根素优化组合治疗缺血性心律失常的活性。国家自然科学基金资助项目。NO39970850
 3
钙火花与心脏衰老及钙火花学中若干基本问题的研究。国家重点基础研究发展规划资助项目(973项目)。NO: G2000057002
 4
钙调蛋白调节心肌兴奋-收缩耦联的分子机制。NO:30200088


获奖情况:
获得2001年度中国高校科学技术奖自然科学二等奖
获得2004年中华医学科技奖三等奖