吴照球

发布者:基础医学发布时间:2016-03-14浏览次数:2796


吴照球,中国药科大学基础医学与临床药学学院和天然药物活性组分与药效国家重点实验室课题组长、博士生导师、江苏特聘教授、江苏省“杰出青年”基金获得者。2006年毕业于中国科学院上海药物研究所,获药理学博士学位。2006 ~ 2008年在美国普渡大学生物化学系与癌症研究中心从事博士后研究工作。2008 ~ 2014年在美国密西根大学生命科学研究所与综合癌症研究中心从事研究工作,先后任博士后研究助理、研究助理教授(non-tenure track)。20147月入选“江苏特聘教授”人才计划,201412月全职回中国药科大学工作。目前的主要研究方向包括:抗肿瘤靶向创新药物发现与研究、恶性肿瘤发生与转移分子机制研究、肿瘤耐药发生机制与逆转策略研究。

回国独立开展工作5年来,在Nature Cell BiologyScience AdvancesJournal of Clinical InvestigationNature Communications2)等综合或专业权威期刊发表通讯(共同通讯)作者研究论文7篇,申请5项中国专利(授权2项)和1PCT国际专利。主持国家自然科学基金面上项目和重大研究计划培育项目3、江苏省自然科学基金“杰出青年”基金项目,入选江苏省“高层次创新创业人才计划”创新团队与创新个人、“江苏特聘教授”、江苏省“六大人才高峰”(A类)等省级人才计划。2019年获江苏省优秀博士学位论文指导教师称号。2015年获江苏省科学技术奖一等奖,2019年获江西省科学技术奖。2018年起担任德国病理学会官方期刊Pathology - Research and Practice副主编。


联系方式:zqwu@cpu.edu.cn;南京市江宁区龙眠大道639号,中国药科大学江宁校区医学实验楼107


5年内发表的代表性论著

  1. Ting Ni#; Xiao-Yan Li#; Na Lu#; Teng An; Zhi-Ping Liu; Rong Fu; Wen-Cong Lv; Yi-Wei Zhang; Xiao-Jun Xu; R. Grant Rowe; Yong-Shun Lin; Amanda Scherer; Tamar Feinberg; Xiao-Qi Zheng; Bao-An Chen; X. Shirley Liu; Qing-Long Guo; Zhao-Qiu Wu*; Stephen J. Weiss*; Snail1-dependent p53 repression regulates expansion and activity of tumor-initiating cells in breast cancer, Nature Cell Biology, 2016, 18: 1221-1232.

  2. Hong-Mei Li#; Yan-Ran Bi#; Yang Li#; Rong Fu#; Wen-Cong Lv; Nan Jiang; Ying Xu; Bo-Xue Ren; Ya-Dong Chen; Hui Xie; Shui Wang; Tao Lu*; Zhao-Qiu Wu*; A potent CBP/p300-Snail interaction inhibitor suppresses tumor growth and metastasis in wild-type p53-expressing cancer, Science Advances, 2020, 6: 1-17.

  3. Rong Fu#; Yi Li#; Nan Jiang#; Bo-Xue Ren#; Chen-Zi Zang; Li-Juan Liu; Wen-Cong Lv; Hong-Mei Li; Stephen Weiss; Zheng-Yu Li; Tao Lu; Zhao-Qiu Wu*; Inactivation of endothelial ZEB1 impedes tumor progression and sensitizes tumors to conventional therapies, Journal of Clinical Investigation, 2020, 130: 1252-1270.

  4. Rong Fu#; Wen-Cong Lv#; Ying Xu#; Mu-Yun Gong#; Xiao-Jie Chen; Nan Jiang; Yan Xu; Qing-Qiang Yao; Lei Di; Tao Lu; Li-Ming Wang; Ran Mo; Zhao-Qiu Wu*; Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis, Nature Communications, 2020, 11: 1-16.

  5. Rong Fu#; Chen-Feng Han#; Ting Ni#; Lei Di#; Li-Juan Liu; Wen-Cong Lv; Yan-Ran Bi; Nan Jiang; Yin He; Hong-Mei Li; Shui Wang; Hui Xie; Bao-An Chen; Xiao-Sheng Wang; Stephen J. Weiss; Tao Lu; Qing-Long Guo; Zhao-Qiu Wu*; A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumors, Nature Communications, 2019, 10: 1-13.

  6. Lei Di#; Li-Juan Liu#; Yong-Ming Yan#; Rong Fu; Yi Li; Ying Xu; Yong-Xian Cheng*; Zhao-Qiu Wu*; Discovery of a natural small-molecule compound that suppresses tumor EMT, stemness and metastasis by inhibiting TGFβ/BMP signaling in triple-negative breast cancer, Journal of Experimental & Clinical Cancer Research, 2019, 38: 1-15.

  7. Rong Fu#; Yi-Wei Zhang#; Hong-Mei Li#; Wen-Cong Lv; Li Zhao; Qing-Long Guo; Tao Lu; Stephen J Weiss; Zhi-Yu Li; Zhao-Qiu Wu*; LW106, a novel indoleamine 2,3-dioxygenase 1 inhibitor, suppresses tumor progression by limiting stroma-immune crosstalk and cancer stem cell enrichment in tumor microenvironment, British Journal of Pharmacology, 2018, 175: 3034-3049.