吴照球

发布者:基础医学发布时间:2016-03-14浏览次数:613

  吴照球,男,教授,博士生导师。2006年毕业于中国科学院上海药物研究所,获药理学博士学位。2006年至2009年在美国普渡大学生物化学系及癌症研究中心从事博士后研究工作,2009年至2014年在美国密歇根大学分子医学及遗传学系、生命科学研究所先后任研究教员和研究助理教授。20149月入选江苏特聘教授人才计划,12月加入中国药科大学。近年来,已在包括Nature CommunicationsPNASJ Biol ChemMol Pharmacol等国际著名期刊上发表研究论文7篇,论文他引超过500次数。为十多个国际生物医学及药理学期刊(包括J Biol ChemMol PharmacolEu J PharmacolActa Pharmacol Sin等)特邀审稿人。现担任美国生理学会官方杂志-Am J Physiol Gastrointest Liver Physiol.IF: 3.8)编委。

研究方向:转基因肿瘤动物模型构建、肿瘤侵袭与转移、肿瘤上皮间质转化、肿瘤血管生成、肿瘤干细胞、抗肿瘤药物开发。

主持基金:

国家自然科学基金面上项目(2016~2019)、国家自然科学基金重大研究计划(2016~2018)、江苏省“双创团队”(2015~2018)。

近年代表性论文

1. Zhao-Qiu Wu, Grant R Rowe, Kim-Chew Lim, Yongshun Lin, Tamar Y Feinberg, Xiaoyan Li, Ivan Maillard, and Stephen J Weiss. A Snail1/Notch1 signaling Axis controls embryonic vascular development; Nature Communications; 5:1-15 (2014).

2. Zhao-Qiu Wu, Xiaoyan Li, Casey Y Hu, Michael Ford, Celina G Kleer, Stephen J Weiss. Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression; Proc. Natl. Acad. Sci., USA; 109: 16654-16659 (2012).

3. Zhao-Qiu Wu, Thomas Brabletz, Eric Fearon, Amanda L Willis, Casey Yuexian Hu, Xiaoyan Li, Stephen J Weiss. The canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity; Proc. Natl. Acad. Sci., USA; 109: 11312-11317 (2012).

4. Zhao-Qiu Wu and Xiaoqi Liu. Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing; Proc. Natl. Acad. Sci., U.S.A; 105: 1919-1924 (2008).

5. Zhao-Qiu Wu, Xiaoming Yang, Greg Weber and Xiaoqi Liu. Plk1 phosphorylation of TRF1 is essential for its binding to telomeric DNA; J. Biol. Chem; 283: 25503-25513 (2008).

6. Zhao-Qiu Wu, Jie Chen, Zhi-Qiang Chi, Jing-Gen Liu. Involvement of dopamine system in regulation of Na,K-ATPase in the striatum upon activation of opiod receptors by morphine; Mol Pharmacol; 71: 519-530 (2007).

7. Zhao-Qiu Wu, Mu Li, Jie Chen, Zhi-Qiang Chi, Jing-Gen Liu. Involvement of cAMP/cAMP-dependent protein kinase signaling pathway in regulation of Na,K-ATPase upon activation of opiod receptors by morphine; Mol Pharmacol; 69: 866-876 (2006).

8. Zhao-Qiu Wu, Qing-Long Guo, Qi-Dong You, Li Zhao, Hong-Yan Gu. Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells; Biol Pharm Bull; 27: 1768-1774 (2004).  

联系方式

zqwu@cpu.edu.cn