姓 名: | 刘景根 | 性 别: | 男 |
职 称: | 研究员 | 学 历: | 博士 |
电 话: | 021-50807588 | 传 真: | |
电子邮件: | jgliu@mail.shcnc.ac.cn | 个人主页: | |
通讯地址: | 上海市浦东新区张江高科技园区祖冲之路555号 201203 |
简历: |
刘景根教授长期从事阿片类药物成瘾的细胞和分子机理研究及低成瘾性阿片类镇痛药和戒毒药物研究。已在J Neurosci, J Cell Sci, J Biol Chem, Mol. Pharmacol, J Neurochem, Biochem J, J Pharmacol Exp Ther 和Cell Research等国际学术期刊上发表了40多篇相关研究论文(第一作者或通讯作者)。发表的论文已被他人引用500多次。已获得国际发明专利1项, 国家发明专利4项。研究成果受到国际学术界的瞩目。国际麻醉药品研究学会前主席,阿片研究领域著名专家Dr. Chavkin在国际著名学术刊物分子药理杂志上发表专文对我们的研究成果进行了评述。我们的研究成果还被Nature China选为研究亮点。中国科学报(要闻版面)和北京科技报(科学/新锐版面)也报道过我们的研究成果。此外,刘教授还被邀请为科学通报自然科学基金项目进展栏写评述。 教育经历 工作经历 |
研究方向: |
主要从事阿片类药物成瘾的细胞和分子机理研究及低成瘾性阿片类镇痛药和戒毒药研究。 |
专家类别: |
研究员;百人计划;杰青 |
职务: |
中科院上海药物所研究员、博士生导师、研究组长 |
科研成果: |
一、揭示了阿片类物质戒断负性情绪记忆形成和消退的机制 二、发现阿片类物质引起海马突触可塑性和脑认知功能改变新机制。 |
承担科研项目情况: |
1.973,阿片类物质精神依赖的神经生物学机制,课题负责人,2009-2013 |
社会任职: |
现兼任中国神经精神药理专业委员会常务委员、中国生化和分子药理专业委员会常务委员,河南省天然药物与免疫工程重点实验室学术委员会委员。上海市神经药理学专业委员会主任委员、上海市生理学会常务理事、上海市药理学会理事、上海市第二届禁毒专家委员会委员。浙江大学兼职教授,中国药科大学兼职博士生导师。中国药理学报、药学学报 (英文版)、中国药学(英文版)、中国药理学通报、神经药理学报,中国药物依赖性杂志编委。 |
获奖及荣誉: |
2004年,中国科学院“百人计划”、国家杰出青年科学基金 |
代表论著: |
1. Sun JF, Wang YH, Chai JR, Li FY, Hang A, Lu G, Tao YM, Cheng Y, Chi ZQ, Neumeyer JL, Zhang A, Liu JG, Wang YJ (2014) Pharmacological characterization and therapeutic potential for the treatment of opioid abuse with ATPM-ET, an N-ethyl substituted aminothiazolomorphinan with κ agonist and μ agonist/antagonist activity. Eur J Pharmacol. doi: 10.1016/j.ejphar.2014.06.045. [Epub ahead of print]. 2. Wang WS, Chen ZG, Liu WT, Chi ZQ, He L, Liu JG (2014) Dorsal hippocampal NMDA receptor blockade impairs extinction of naloxone-precipitated conditioned place aversion in acute morphine-treated rats by suppressing ERK and CREB phosphorylation in the basolateral amygdala. Br J Pharmacol. doi: 10.1111/bph.12671. [Epub ahead of print] 3. Li M, Liu WJ, Lu B, Wang YH, Liu JG* (2013) Differential expression of Arc in the mesocorticolimbic system is involved in drug and natural rewarding behavior in rats. Acta Pharmacol Sin 34:1013-1024. 4. Kang S, Ling QL, Liu WT, Lu B, Liu Y, He L, Liu JG* (2013) Down-regulation of dorsal striatal RhoA activity and impairment of working memory in middle-aged rats. Neurobiol Learn Mem103:3-10. 5. Wang J, Wang YH, Hou YY, Xi T, Liu Y, Liu JG* (2013) The small GTPase RhoA, but not Rac1, is essential for conditioned aversive memory formation through regulation of actin rearrangements in rat dorsal hippocampus. Acta Pharmacol Sin 34:811-818. 6. Liu Y, Zhou QX, Hou YY, Lu B, Yu C, Chen J, Ling QL, Cao J, Chi ZQ, Xu L*, Liu JG* (2012) Actin polymerization-dependent increase in synaptic Arc/Arg3.1 expression in the amygdala is crucial for the expression of aversive memory associated with drug withdrawal. J Neurosci 32: 12005-12017. 7. Wang WS, Kang S, Liu WT, Li M, Liu Y, Yu C, Chen J, Zhi-Qiang Ch ZQ, He L, and Jing-Gen Liu JG* (2012) Extinction of aversive memories associated with morphine withdrawal requires ERK-mediated epigenetic regulation of brain-derived neurotrophic factor transcription in the rat ventromedial prefrontal cortex. J Neurosci 32: 13763-13775. 8. Lu G, Zhou QX, Kang S, Li QL, Zhao LC, Chen JD, Sun JF, Cao J, Wang YJ, Chen J, Chen XY, Zhong DF, Chi ZQ, Xu L*, Liu JG* (2010) Chronic morphine treatment impaired hippocampal LTP and spatial memory via accumulation of extracellular adenosine acting on adenosine A1 receptors. J Neurosci 30: 5058-5070. 9. Xu C, Hong MH, Zhang LS, Hou YY, Wang FF, Chen YJ, Xu XJ, Chen J, Xie X, Ma L, Chi ZQ, Liu JG* (2010) Serine 363 Residue of δ-Opioid Receptor is Crucial for Adopting Distinct Pathways to Activate ERK1/2. J Cell Sci 123: 4259-4270. 10. Sun JF, Wang YH, Li FY, Lu G, Tao YM, Cheng Y, Chen J, Xu XJ, Chi ZQ, John L Neumeyer JL, Zhang A, Liu JG* (2010) Effects of ATPM-ET, a novel κ agonist with partial μ activity on morphine physical dependence and expression of morphine sensitization. Acta Pharmacol Sin 31:1547-1552. 11. Lu B, Li M, Hou YY, Chen J, Chi ZQ, Liu JG* (2010) Initial experience of heroin use under a two-chained operant schedule influences drug-seeking behavior after one month of abstinence. Acta Pharmacol Sinica 31: 387-392-1391. 12. Wang YH, Sun JF, Tao YM, Chi ZQ, Liu JG* (2010) The role of kappa-opioid receptor activation in mediating antinociception and addiction. Acta Pharmacol Sin 31:1065-1070. 13. Wang YH, Sun JF, Tao YM, Xu XJ, Chi ZQ, Liu JG, * (2010) Paradoxical relationship between RAVE (relative activity versus endocytosis) values of several opioid receptor agonists and their liability to cause dependence. Acta Pharmacol Sinica 31: 1065-1070. 14. Cheng Y, Tao YM, Sun JF, Wang YH, Xu XJ, Chen J, Chi ZQ, Jing-gen Liu JG* (2010) Adenosine A1 receptor agonist CHA induced phosphorylation of delta opioid receptor and desensitization of its signaling. Acta Pharmacol Sinica 31:784-790. 15. Hou YY, Lu B, Li M, Liu Y, Chen J, Chi ZQ, and Liu JG* (2009) Involvement of actin rearrangements within the amygdala and the dorsal hippocampus in aversive memories of drug withdrawal in acute morphine dependent rats. J Neurosci 29: 12244-12254. 16. Hong MH, Xu C, Wang YJ, Ji JL, Tao YM, Xu XJ, Chen J, Xie X, Zhi-Qiang Chi ZQ, Liu JG* (2009) Role of Src in Ligand-specific Regulation of δ-opioid Receptor Desensitization and Internalization. J Neurochem 108: 102-114. 17. Wang YJ, Tao YM, Xu XJ, Chen J, Cao YL, Chi ZQ, Liu JG* (2009) Pharmacological Characterization of ATPM-AZ, a Novel Mixed κ Agonist and μ Agonist/Antagonist That Attenuates Morphine Antinociceptive Tolerance and Heroin Self-Administration Behavior. J Pharmacol Exp Ther 329: 306-313. 18. Lin X, Wang YJ, Huo YY, Li Q, Chi ZQ, Liu JG* (2009) Morphine promotes SH-SY5Y cell apoptosis through c-Jun N-terminal kinase-mediated activation of mitochondria-dependent apoptosis pathway. FEBS J 276: 2022-2036. 19. Li F, Gao L, Yin C, Chen J, Chi ZQ, Liu JG, Xie X,, Zhang A (2009) Synthesis and opioid receptor activity of indolopropellanes. Bioorg Med Chem Lett 19: 4603-4606. 20. Li W, Tao YM, Ang Y, Xu XJ Chen J, Wang XH, Chao B, Sheng W, Chi ZQ, Qiu ZB*, Liu JG* (2010) Unexpected potent and highly selective μ-opioid agonists discovered by substituting an omitted region of 4, 5-epoxymorphinanes. Bioorg Med Chem Lett 20: 418-421. 21. Li F, Yin C, Chen J, Liu JG, Xie X, Zhang A (2009) Synthesis and SAR study of opioid receptor ligands: mono- and bis-Indolomorphinans. Chem Biol Drug Des 74: 335–342. 22. Li M, Hou YY, Lu B, Chen J, Chi ZQ, Liu JG* (2009) Neural synaptic plasticity marker-Arc expression pattern in different brain regions induced by conditioned drug withdrawal from acute morphine dependent rats. Acta Pharmacol Sinica 30: 282-290. 23. Hou YY, Liu Y, Kang S, Yu C, Chi ZQ, Liu JG* (2009) Glutamate receptors within the dorsal hippocampus mediate the acquisition, but not the expression, of conditioned place aversion induce induced by acute morphine withdrawal. Acta Pharmacol Sinica 30: 1385-1391. 24. Li F, Yin C, Chen J, Liu JG*, Xie X*, Zhang A* (2009) [6,7]-Heterocycle-Fused 14-Hydroxymorphinan derivatives: design, synthesis, and opioid receptor activity ChemMedChem 4:2103-2110. |