王小晟

发布者:基础医学发布时间:2016-03-14浏览次数:2139

王小晟,博士,副教授,博士生导师。2010年获日本京都大学生物信息学博士学位2010年至2013年在美国国立卫生研究院(NIH/NCI)从事博士后研究工作,2013年至2015年在美国内布拉斯加大学医学中心(UNMC)任讲师。201510加入中国药科大学。作为主要贡献者已发表SCI论文30余篇,现任Journal of Oncology, the World Journal of Gastrointestinal Oncology等国际杂志编委,为Journal of the National Cancer Institute, Nucleic Acids Research,Journal for ImmunoTherapy of Cancer, Neoplasia, BMC Bioinformatics, BMC Cancer, Computer Methods and Programs in Biomedicine等国际杂志审稿专家,The European Research Council Consolidator 基金和The Israel Science Foundation (ISF) 基金评审专家。


研究方向:生物信息学, 癌症基因组学, 药物信息学,系统生物学,生物统计学。


近年代表性论文 (*corresponding author)

  1. Lin Li, Qiushi Feng, Xiaosheng Wang*, PreMSIm: an R package for predicting microsatellite instability from the expression profiling of a gene panel in cancer, Computational and Structural Biotechnology Journal, 2020, doi: 10.1016/j.csbj.2020.03.007.

  2. Lin Li, Mengyuan Li, Xiaosheng Wang*, Cancer type-dependent correlations between TP53 mutations and antitumor immunity, DNA Repair, 2020, doi: 10.1016/j.dnarep.2020.102785. 

  3. Zehang Jiang#, Zhixian Liu#, Mengyuan Li, Cai Chen, Xiaosheng Wang*, Increased glycolysis correlates with elevated immune activity in tumor immune microenvironment, EBioMedicine, 2019, 42(2019): 431-442

  4. Md. Nazim Uddin, Mengyuan Li, Xiaosheng Wang*, Identification of Transcriptional Markers and microRNA–mRNA Regulatory Networks in Colon Cancer by Integrative Analysis of mRNA and microRNA Expression Profiles in Colon Tumor Stroma, Cells, 2019 (8), 1054.

  5. Rong Fu, Chen-Feng Han, Ting Ni, Xiao-Sheng Wang, Zhao-Qiu Wu*. A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours, Nature Communications, 2019, 10(1): 3210.

  6. Haoyu Lyu#, Mengyuan Li#, Zehang Jiang, Zhixian Liu, Xiaosheng Wang*, Correlate the TP53 Mutation and the HRAS Mutation with Immune Signatures in Head and Neck Squamous Cell Cancer, Computational and Structural Biotechnology Journal, 2019, 17: 1020–1030.

  7. Lin Li, Mengyuan Li, Zehang Jiang, Xiaosheng Wang*, ARID1A Mutations Are Associated with Increased Immune Activity in Gastrointestinal Cancer, cells, 2019, 8(7): 678.

  8. Inas Elsayed, Xiaosheng Wang*, PLK1 inhibition in cancer therapy: potentials and challenges, Future Med Chem, 2019, 11(12): 1383-1386. 

  9. Zhixian Liu, Zehang Jiang, Yingsheng Gao, Lirui Wang, Cai Chen, Xiaosheng Wang*, TP53 Mutations Promote Immunogenic Activity in Breast Cancer, Journal of Oncology, 2019, Article ID 5952836: 19.

  10. Ying He, Zhixian Liu, Zehang Jiang, Xiaosheng Wang*, Identification of genomic features associated with immunotherapy response in gastrointestinal cancers. World Journal of Gastrointestinal Oncology, 2019, 11(4): 270-280.

  11. Xiaosheng Wang*, Mengyuan Li, Correlate tumor mutation burden with immune signatures in human cancers, BMC Immunology, 2019, 20: 4.

  12. Yin He, Zehang Jiang, Cai Chen, Xiaosheng Wang*, Classification of triple-negative breast cancers based on Immunogenomic profiling, Journal of Experimental & Clinical Cancer Research, 2018, 37(1): 327.

  13. Mengyuan Li, Zhixian Liu, Xiaosheng Wang*, Exploration of the Combination of PLK1 Inhibition with Immunotherapy in Cancer Treatment, Journal of Oncology, 2018, Article ID 3979527: 13.

  14. Qingrong Sun, Mengyuan Li, Xiaosheng Wang*, The Cancer Omics Atlas: an integrative resource for cancer omics annotations, BMC medical genomics, 2018, 11(1): 3.

  15. Zehang Jiang, Zhixian Liu, Mengyuan Li, Cai Chen, Xiaosheng Wang*, Immunogenomics Analysis Reveals that TP53 Mutations Inhibit Tumor Immunity in Gastric Cancer, Translational oncology, 2018, 11(5): 1171-1187.

  16. Zhixian Liu, Mengyuan Li, Zehang Jiang, Xiaosheng Wang*, A Comprehensive Immunologic Portrait of Triple-Negative Breast Cancer. Translational Oncology, 2018, 11 (2): 311-329.

  17. Nalin C. W. Goonesekere*, Wyatt Andersen, Alex Smith, Xiaosheng Wang*,Identification of genes highly downregulated in pancreatic cancer through a meta-analysis of microarray datasets: implications for discovery of novel tumor-suppressor genes and therapeutic targets, Journal of Cancer Research and Clinical Oncology, 2017, 114 (2): 309-320.

  18. Zhixian Liu, Qingrong Sun, Xiaosheng Wang*, PLK1, a Potential Target for Cancer Therapy, Translational Oncology, 2017, 10(1):22-32.

  19. Suleyman Vural, Xiaosheng Wang, Chittibabu Guda*, Classification of breast cancer patients using somatic mutation profiles and machine learning approaches, BMC Systems Biology,2016, 10(Suppl 3): 62.

  20. Ru Shen, Xiaosheng Wang, Chittibabu Guda*, Discovering Distinct FunctionalModules from Cancer Protein-protein Interaction Networks. Biomed ResearchInternational, 2015, 2015: 146365.

  21. Xiaosheng Wang, Chittibabu Guda*, Computational analysis of transcriptionalcircuitries in human embryonic stem cells reveals multiple and independent networks,Biomed Research International, 2014(1): 103-113.

  22. Xiaosheng Wang*, Identification of Marker genes for Cancer Based on Microarrays Using aComputational Biology Approach, Current Bioinformatics 2014, 9(2): 140-146.

  23. Xiaosheng Wang*, Richard Simon*, Identification of potential synthetic lethal genes to p53 using acomputational biology approach, BMC Medical Genomics 2013, 6: 30.

  24. Xiaosheng Wang*, Discovering molecular associations between ageing, stem cell, and cancerbased on gene expression profiling, Chinese Journal of Cancer 2013, 32(4): 155-161.

  25. Xiaosheng Wang*, Robust Two-gene Classifiers for Cancer Prediction. Genomics,2012, 99(2):90-95.

  26. Xiaosheng Wang*, Microarray Analysis of Ageing-related Signatures and Their Expression in Tumors Based on a Computational Biology Approach, Genomics, Proteomics & Bioinformatics, 2012, 10(3): 136-141.

  27. Xiaosheng Wang, Richard Simon*, Microarray-based Cancer Prediction Using Single Genes, BMCBioinformatics, 2011, 12:391.

  28. Xiaosheng Wang*, Osamu Gotoh, Accurate Molecular Classification of Cancer Using SimpleRules, BMC Medical Genomics, 2009, 2: 64.



软件

1. A Single-Gene Classifier(developer: Xiaosheng Wang)

A plugin software with the BRB-ArrayTools (https://brb.nci.nih.gov/BRB-ArrayTools/).

2. A Two-Gene Classifier(developer: Xiaosheng Wang)

A plugin software with the BRB-ArrayTools (https://brb.nci.nih.gov/BRB-ArrayTools/).

3. The Cancer Omics Atlas: An integrative resource for cancer omics annotations

(developer: Xiaosheng Wang,Qingrong Sun, Mengyuan Li)

This is a web tool (TCOA, http://tcoa.cpu.edu.cn) providing fast and straightforward querying of TCGA (https://portal.gdc.cancer.gov/) gene expression, somatic mutations, microRNA expression, protein expression data.



联系方式
E-mail: xiaosheng.wang@cpu.edu.cn xiaosheng.wang@hotmail.com