颜天华

发布者:基础医学发布时间:2016-03-13浏览次数:154

1.学习工作经历
颜天华,男,汉族,1969年8月生,浙江温岭市人,党员,中国药科大学药学院生理教研室副教授,硕士生导师。1991年7月毕业于中国药科大学获学士学位,1998年7月毕业于第二军医大学获药理硕士学位,2008年7月于中国药科大学获药理博士学位。2005年1月至今,于中国药科大学药学院工作,长期承担本科各专业《人体解剖生理学》的理论与实验授课任务,授课质量优良。承担硕士研究生《心血管药理学》和《当代药理学》的教学工作,指导硕士研究生及辅助指导博士研究生多名。
2.研究方向
长期从事心血管药物的药理研究及新药评价,主要研究方向是心血管药理学,特别是心脑血管疾病(如冠心病,脑卒中等)及糖尿病研究,为新药的发现提供新的方法。
3.科研课题
主要从事心血管药理及新药评价工作,负责多项国家及省部级的科研课题和横向新药开发项目。主持完成“十一五重大专项”治疗糖尿病候选药物CW7213的研究(146万),目前正主持及参与国家“十二五国家重大专项”防治心肌缺血再灌注损伤化学1类新药TG-6的成药性研究(126万)和“十二五国家重大专项”化学1类创新药红景天苷原料及制剂临床前部分药学及药效学研究(170万)。参与863计划课题、国家自然科学基金各1项。 
4.近年来发表的论著
在国内外核心期刊发表论文30余篇,其中被SCI收载论文20余篇。主编1部(43万字)《人体解剖生理学》,东南大学出版社出版。副主编1部(48万字)《生理学实验与指导》,中国医药科技出版社出版。参编3部。
5.获得专利情况
(1)化合物对大鼠心肌缺血再灌注损伤的保护作用(申请号:200910025743.3)
(2)多肽CW7213纯化工艺方法(申请号:201110003682.8)

论文发表
1. Zhang L, Yan L, Jiang J, Wang Y, Jiang Y, Yan T*, Cao Y*.The structure and retrotransposition mechanism of LTR-retrotransposons in the asexual yeast Candida albicans. Virulence. 2014 Aug 15;5(6):655-664.
2.Wang J, Xiao L, Zhu L, Hu M, Wang Q, Yan T*.The Effect of Synthetic Salidroside on Cytokines and Airway Inflammation of Asthma Induced by Diisocyanate (TDI) in Mice by Regulating GATA3/T-bet. Inflammation. 2014 Jul 23.
3.Wang J , Liu YT, Xiao L, Zhu L, Wang Q, Yan T*.Anti-Inflammatory Effects of Apigenin in Lipopolysaccharide-Induced Inflammatory in Acute Lung Injury by Suppressing COX-2 and NF-kB Pathway. Inflammation. 2014 Jun 24.
4.Yan T, Fu Q, Wang J, Ma S. UPLC-MS/MS determination of ephedrine, methylephedrine, amygdalin and glycyrrhizic acid in Beagle plasma and its application to a pharmacokinetic study after oral administration of Ma Huang Tang. Drug Test Anal. 2014 May 13. doi: 10.1002/dta.1635.
5.Yu S, Chai X, Wang Y, Cao Y, Zhang J, Wu Q, Zhang D, Jiang Y, Yan T*, Sun Q*. Triazole derivatives with improved in vitro antifungal activity over azole drugs. Drug Des Devel Ther. 2014 Apr 10; 8:383-90.
6.Jiang J, Zhao L, Yan L, Zhang L, Cao Y, Wang Y, Jiang Y, Yan T*, Cao Y*. Structural features and mechanism of translocation of non-LTR retrotransposons in Candida albicans. Virulence. 2014 Feb 15;5(2):245-52.
7.Yao J, Hu R, Sun J, Lin B, Zhao L, Sha Y, Zhu B, You QD, Yan T*, Guo QL*. Oroxylin A prevents inflammation-related tumor through down-regulation of inflammatory gene expression by inhibiting NF-κB signaling. Mol Carcinog. 2014 Feb; 53(2):145-58.
8.Fu R, Yan T, Wang Q, Guo Q, Yao H, Wu X, Li Y. Suppression of endothelial cell adhesion by XJP-1, a new phenolic compound derived from banana peel. Vascul Pharmacol. 2012 Sep-Oct; 57(2-4):105-12.
9.Wang Y, Yan T, Wang Q, Wang W, Xu J, Wu X, Ji H. PKC-dependent extracellular signal-regulated kinase 1/2 pathway is involved in the inhibition of Ib on AngiotensinII-induced proliferation of vascular smooth muscle cells. Biochem Biophys Res Commun. 2008 Oct 10; 375(1):151-5.
10. Yang F, Yan TH, Rustchenko E, Gao PH, Wang Y, Yan L, Cao YY, Wang QJ, Ji H, Cao YB, Jiang YY High-frequency genetic contents variations in clinical Candida albicans isolates.Biol Pharm Bull. 2011; 34(5):624-31.
11 Xiao-Qing LIANG, Pei XIE, Yong ZHANG, Tao Shi, Tian-Hua YAN*, Qiu-Juan WANG* Effects of Salidroside on Myocardial Ischemia/Reperfusion Injury in Rats
Chinese Journal of Natural Medicines 2010, ISSN 1672-3651 CN 32-1708/R
12 Tian-Hua YAN, Bao-Sheng DU, Wei YANG, Ying MA, Jing XU, Qiu-Juan WANG Effects of Salidroside on Hemorheology and Myocardia Ischemic Reperfusion Injury in Isolated Heart of Rats Chinese Journal of Natural Medicines 2008 ISSN 1672-3651 CN 32-1708/R
13 Liu LP, Yan TH, Jiang LY, Hu W, Hu M, Wang C, Zhang Q, Long Y, Wang JQ, Li YQ, Hu M, Hong H. Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain β-amyloid through PPARγ activation.Acta Pharmacol Sin. 2013 Apr;34(4):455-63. doi: 10.1038/aps.2013.11. 
14 Qing Shan Liu, Ke Qin Li, Jun Li, Xiao Ying Yin, Tian Hua Yan* A Novel Method for Prepairing higher performance Picroside I Surface Molecularly Imprinted Polymers for TCM Research. Advanced Materials Research September 2013, 642-645.
15 Pretreatment with antiasthmatic drug ibudilast ameliorates Aβ1-42-induced memory impairment and neurotoxicity in mice. Wang H, Mei ZL, Zhong KL, Hu M, Long Y, Miao MX, Li N, Yan TH*, Hong H*. Pharmacol Biochem Behav. 2014 Sep; 124:373-9. doi: 10.1016/j.pbb.2014.07.006. 
16 Zhu L, Wang J ,Wei T, He H , Gao J, Chang X, Yan T* Effects of naringenin on inflammation in complete Freund's adjuvant-induced arthritis by regulating Bax/Bcl-2 balance Inflammation 2014.doi:10.1007/s10753-014-0027-7.
17 Yan T, Wang J, Zhu L Yan T* Apigenin attenuates heart injury in lipopolysaccharide-induced endotoxemia rat model by suppressing sphingosine kinase1/sphingosine1-phosphate signaling pathway. PLOS ONE 2014(Accepted)
18 Xiayun Chang, He He, Lingpeng Zhu, Jin Gao, Tingting Wei, Zhanqian Ma, Tianhua Yan* Protective effect of apigenin on Freund’s complete adjuvant-induced
arthritis in rats via inhibiting P2X7/NF-jB pathway Chemico-Biological Interactions 236 (2015) 41–46
19 Jin Gao , He He, Wenjiao Jiang , Xiayun Chang , Lingpeng Zhu , Fen Luo , Rui Zhou ,Chunhua Ma , Tianhua Yan* Salidroside ameliorates cognitive impairment in a
d-galactose-induced rat model of Alzheimer’s disease Behavioural Brain Research 293 (2015) 27–33
20 Lingpeng Zhu, Tingting Wei, Jing Gao, Xiayun Chang, He He, Mingxing Miao ,Tianhua Yan* Salidroside attenuates lipopolysaccharide (LPS) induced serum 
cytokines and depressive-like behavior in mice Neuroscience Letters 606 (2015) 1–6
21 Xiayun Chang, Fen Luo, Wenjiao Jiang , Lingpeng Zhu, Jin Gao , He He , Tingting Wei, Shilin Gong, Tianhua Yan* Protective activity of salidroside against ethanol-induced gastric ulcer via the MAPK/NF-κB pathway in vivo and in vitro International Immunopharmacology 28 (2015) 604–615
22 He He, Xiayun Chang, Jin Gao, Lingpeng Zhu, Mingxing Miao, Tianhua Yan* Salidroside Mitigates Sepsis-Induced Myocarditis in Rats by Regulating IGF-1/PI3K/Akt/GSK-3β Signaling Inflammation (#2015)DOI: 10.1007/s10753-015
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