徐明

发布者:基础医学发布时间:2017-09-14浏览次数:15


徐明,博士,副教授,博士生导师。2006年获安徽医科大学药理学硕士学位,2009年获中国药科大学药理学博士学位。2009年赴美国Virginia Commonwealth University从事博士后研究,20149月作为海外高层次引进人才进入中国药科大学工作。已发表SCI期刊论文28篇,多次参加国际学术会议,发表会议论文16篇。担任Oncotarget,Cellular Physiology & BiochemistrySCI期刊审稿人。目前作为负责人主持以下国家和省部级科研项目:十三五“重大新药创制”科技重大专项(2017ZX09301066),国家自然科学基金面上项目(81773732),江苏省自然科学基金面上项目(BK20161461),国家自然科学基金面上项目(81570413),中央高校基本科研业务费项目,中国药科大学高层次引进人才启动基金等。同时担任国家自然科学基金青年项目、国家重点研发计划重大慢病专项等项目评审专家。20169月赴英国伦敦大学学院交流访问,201610月赴美国加州大学洛杉矶分校参与高等教育教学法研修项目。担任全国高等学校药学专业第八轮规划教材《药学服务概论》编委。


研究方向

 1.合理用药与临床药物评价

 2. 心血管药理学


联系方式

 mingxu2016@163.com


代表论文

1Lv ZH, Phuong TA, Jin SJ, Li XX, Xu M(corresponding author).Protection by simvastatin on hyperglycemia-induced endothelial dysfunction through inhibiting NLRP3 inflammasomes. Oncotarget (Accepted)

2Li Q, Li J, Shao H, Li XX, Yu F, Xu M(corresponding author). Inhibition of CPU0213, a Dual Endothelin Receptor Antagonist, on Apoptosis via Nox4-Dependent ROS in HK-2 Cells. Cell Physiol Biochem. 2016; 39(1):183-92.

3Li J, Zhang L, Jiang Z, He X, Zhang L, Xu M(corresponding author). Expression of Renal Aquaporins in Aristolochic Acid I and Aristolactam I-Induced Nephrotoxicity. Nephron. 2016; 133(3):213-21.

4Xu M, Hu C, Khan HH, Shi FH, Cong XD, Li Q, Dai Y, Dai DZ. Argirein alleviates stress-induced and diabetic hypogonadism in rats via normalizing testis endothelin receptor A and connexin 43.Acta Pharmacol Sin. 2016; 37(2):246-54.

5Xu M, Zhang Q, Li PL, Nguyen T, Li X, Zhang Y. Regulation of dynein-mediated autophagosomes trafficking by ASM in CASMCs.Front Biosci (Landmark Ed). 2016; 21:696-706.

6Xu M, Li XX, Wang L, Wang M, Zhang Y, Li PL. Contribution of Nrf2 to Atherogenic Phenotype Switching of Coronary Arterial Smooth Muscle Cells Lacking CD38 Gene. Cell Physiol Biochem. 2015; 37:432-44.

7Xu M, Li XX, Chen Y, Pitzer AL, Zhang Y, Li PL. Enhancement of dynein-mediated autophagosome trafficking and autophagy maturation by ROS in mouse coronary arterial myocytes. J Cell Mol Med. 2014; 18(11):2165-75.

8Zhang Y, Xu M (Co-first author), Xia M, Li X, Boini KM, Wang M, Gulbins E, Ratz PH, Li PL. Defective autophagosome trafficking contributes to impaired autophagic flux in coronary arterial myocytes lacking CD38 gene. Cardiovasc Res. 2014; 102(1):68-78.

9Xu M, Li XX, Xiong J, Xia M, Gulbins E, Zhang Y, Li PL. Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes. Biochim Biophys Acta. 2013; 1833(12):3228-36.

10Xu M, Li XX, Ritter JK, Abais JM, Zhang Y, Li PL. Contribution of NADPH oxidase to membrane CD38 internalization and activation in coronary arterial myocytes. PLoS One. 2013; 8(8):e71212.

11Xu M, Li X, Walsh SW, Zhang Y, Abais JM, Boini KM, Li PL. Intracellular two-phase Ca2+ release and apoptosis controlled by TRP-ML1 channel activity in coronary arterial myocytes. Am J Physiol Cell Physiol. 2013; 304(5):C458-66.

12Xu M, Xia M, Li XX, Han WQ, Boini KM, Zhang F, Zhang Y, Ritter JK, Li PL. Requirement of translocated lysosomal V1 H(+)-ATPase for activation of membrane acid sphingomyelinase and raft clustering in coronary endothelial cells. Mol Biol Cell. 2012; 23(8):1546-57.

13Xu M, Zhang Y, Xia M, Li XX, Ritter JK, Zhang F, Li PL.NAD(P)H oxidase-dependent intracellular and extracellular O2•- production in coronary arterial myocytes from CD38 knockout mice. Free Radic Biol Med. 2012; 52(2):357-65.

14Xu M, Tang YQ, Dai DZ, Zheng YF, Cheng YS, Zhang Q, Dai Y. Comparison of sildenafil with strontium fructose diphosphate in improving erectile dysfunction against upregulated cavernosal NADPH oxidase, protein kinase Cå, and endothelin system in diabetic rats. J Pharm Pharmacol. 2012; 64(2):244-51.

15Xu M, Dai DZ, Zhang Q, Cheng YS, Dai Y. Upregulated NADPH oxidase contributes to diabetic testicular complication and is relieved by strontium fructose 1,6-diphosphate. Exp Clin Endocrinol Diabetes. 2010; 118(7):459-65.

16Xu M, Ji H, Dai DZ, Tang XY, Dai Y. Protective effect of the endothelin antagonist CPU0213 against isoprenaline-induced heart failure by suppressing abnormal expression of leptin, calcineurin and SERCA2a in rats. J Pharm Pharmacol. 2008; 60(6):739-45.

17Xu M, Dai DZ, Dai Y. Normalizing NADPH Oxidase Contributes to Attenuating Diabetic Nephropathy by a Dual Endothelin Receptor Antagonist CPU0213 in Rats. Am J Nephrol. 2008; 29(3):252-6.