卢杨

发布者:基础医学发布时间:2017-09-14浏览次数:10

卢杨,副研究员,硕士生导师
专业研究方向:药物代谢动力学

2006年毕业于中国药科大学药学专业,获得药学学士学位,
2006-2007年在辉瑞制药工作,2007年于中国药科大学药物代谢动力学专业攻读硕士学位,于2010年获得硕士学位,同年获得日本文部科学省奖学金资助,赴日本金泽大学师从著名药动学家Ikumi Tamai教授进行药物转运体方面的研究,于2013年获得博士学位。毕业后被聘为金泽大学博士研究员,后赴美国北卡莱罗纳大学教堂山分校药学院从事药物转运体方面的博士后研究。2016年加入中国药科大学,现在基础医学与临床药学学院临床药物代谢动力学研究室工作。迄今共发表SCI论文30余篇,其中以第一作者发表在《Drug Metabolism and Disposition》、《Toxicological Sciences》等本领域权威期刊8篇。

研究方向
1.疾病状态下药物转运体的调控机制及对药物处置的影响;
2. 纳米靶向药物体内转运机制研究。

代表性论文:
1. Yang Lu, Jason R. Slizgi, Kenneth R. Brouwer, Robert L. St. Claire, Kimberly M. Freeman, Maxwell Pan, William J. Brock, Kim L.R. Brouwer. Hepatocellular disposition and transporter interaction of tolvaptan and metabolites in human sandwich-cultured hepatocytes. Drug Metabolism and Disposition. 2016 (in press)
2. Jason R. Slizgi, Yang Lu (equal contribution), Kenneth R. Brouwer, Robert L. St. Claire, Kimberly M. Freeman, Maxwell Pan, William J. Brock, Kim L.R. Brouwer. Inhibition of human hepatic bile acid transporters by tolvaptan and metabolites: A contributing factor to drug-induced liver injury. Toxicological Sciences. 2016,149: 237-250.
3. Yang Lu, Takeo Nakanishi, Hosomi Atsushi, Hisakazu Komori, Ikumi Tamai. In-vitro evidence of enhanced BCRP-mediated intestinal urate secretion by uremic toxins in Caco-2 cells. Journal of Pharmacy and Pharmacology. 2015, 67:170-177.
4. Yang Lu, Takeo Nakanishi, Miki Fukazawa, Ikumi Tamai. How does whisky lower serum urate level? Phytotherapy Research. 2014, 28: 788-790.
5. Yang Lu, Jing Jing, Weichao Ren, Jing Zhu, Zhixia Qiu, Ning Li, Xiaonan Li, Di Zhao, Harendra S. Parekh, Xijing Chen. Biliary excretion of glycyrrhetinic acid: glucuronide-conjugate determination following a pharmacokinetic study of rat bile. Phytotherapy Research. 2014, 28: 1887-1889.
6.Yang Lu, Takeo Nakanishi, Ikumi Tamai. Functional cooperation of SMCTs and URAT1 for renal reabsorption transport of urate. Drug Metabolism and Pharmacokinetics. 2013, 28 (2): 153-158.
7. Fang Fang, Yang Lu, Yue Liang, Jing Zhu, Jiake He, Jianheng Zheng, Ning Li, Yue Tang, Jiabi Zhu, Xijing Chen. Evaluation of insulin lispro and biosynthetic human insulin in pulmonary absorption: in vivo and in vitro studies. Pharmazie. 2012, 67: 706-711.
8. Bing Yang, Yang Lu (equal contribution), Jianheng Zheng, Jing Zhu, Jiake He, Di Zhao, Pengfei Song,  Xijing Chen. Pharmacokinetics of the prodrug thiamphenicol glycinate and its active parent compound thiamphenicol in beagle dogs following intravenous administration. Xenobiotica. 2011, 41: 226-231.
9. Weichao Ren, Yang Lu, Jing Jing, Jing Zhu, Di Wan, Di Zhao, Jianheng Zheng, Fang Fang, Yan He, Xijing Chen. Determination of glycyrrhizin in dog plasma by liquid chromatography-mass spectrometry and its application in pharmacokinetic studies. European Journal of Mass Spectrometry. 2010, 16: 673-678.
10. Yang Lu, Jing Zhu, Xijing Chen, Ning Li, Feifei Fu, Jiake He, Guangji Wang, Lingli Zhang, Yi Zheng, Zhixia Qiu, Xue Yu, Deen Han, Lei Wu. Identification of human UDP-glucuronosyltransferase isoforms responsible for the glucuronidation of glycyrrhetinic acid. Drug Metabolism and Pharmacokinetics. 2009, 24: 523-528.
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