张小博

发布者:基础医学发布时间:2017-09-19浏览次数:1416


张小博,男,副教授,硕士生导师,西北农林科技大学与美国田纳西大学联合培养博士,2013年底获理学博士,2014年入职中国药科大学。主要从事天然产物及非甾体抗炎药物肿瘤药理学研究及抗肿瘤创新药物开发的工作。目前研究方向包括:肝癌体内外模型建立及天然药物干预机制研究、肿瘤微环境调控机制及靶向药物开发。近年来,主持中央高校基本科研业务费项目(2015PY013)、国家自然科学青年项目(81503098)和面上项目(81973522),参与多项国家和省部级课题及抗肿瘤新药的研发工作。

代表性论文:

Sun J, Tao R, Mao T, Feng Z, Guo Q, Zhang X*. The involvement of lipid raft pathway in suppression of TGFβ-mediated metastasis by tolfenamic acid in hepatocellular carcinoma cells. Toxicol Appl Pharmacol. 2019, 380:114696.

Zhang X, Liu Y, Lu L, Huang S, Ding Y, Zhang Y, Guo Q, Li Z, Zhao L. Oroxyloside A Overcomes Bone Marrow Microenvironment-Mediated Chronic Myelogenous Leukemia Resistance to Imatinib via Suppressing Hedgehog Pathway. Front Pharmacol. 2017, 8:526.

Zhang X, Kang Y, Huo T, Tao R, Wang X, Li Z, Guo Q, Zhao L. GL-V9 induced upregulation and mitochondrial localization of NAG-1 associates with ROS generation and cell death in hepatocellular carcinoma cells. Free Radic Biol Med. 2017, 112:49-59.

Zhang X, Sukamporn P, Zhang S, Min KW, Baek SJ. 3,3'-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells. Oncol Rep. 2017, 38(1): 569-574.

Zhang X, Min KW, Liggett JL, Baek SJ. Disruption of the transforming growth factor-β (TGF-β) pathway by tolfenamic acid via the ERK MAP kinase pathway. Carcinogenesis. 2013, 34(12): 2900-2907.

Zhang X, Lee SH, Min KW, McEntee MF, Jeong JB, Li Q, Baek SJ. The involvement of endoplasmic reticulum stress in the suppression of colorectal tumorigenesis by tolfenamic acid. Cancer Prev Res (Phila). 2013, 6(12): 1337-1347.

Zhang X, Min KW, Wimalasena J, Baek SJ. Cyclin D1 degradation and p21 induction contribute to growth inhibition of colorectal cancer cells induced by epigallocatechin-3-gallate. J Cancer Res Clin Oncol. 2012, 138(12):2051-60.


联系地址:南京鼓楼区童家巷24号中国药科大学科研楼1108

电子邮箱:zxb@cpu.edu.cn