魏立彬

发布者:基础医学发布时间:2017-09-19浏览次数:1516

魏立彬,女,1986年出生,药理学博士,副教授,硕士生导师。20146月获得中国药科大学药理学专业博士学位,7月留校任教;20161月被聘为中国药科大学“特聘副研究员”, 7月晋升为副教授。获得2015年“江苏省优秀博士学位论文”荣誉; 2016年入选江苏省教育厅高校“青蓝工程”优秀青年骨干教师培养对象。

依托江苏省肿瘤发生与干预重点实验室和国家科技部肿瘤药效学平台,以天然产物的抗肿瘤作用及机制为主要研究方向,重点研究肿瘤细胞及肿瘤微环境的异常能量代谢机制,以及天然产物来源创新药物干预细胞异常代谢的抗肿瘤作用机制。近几年以第一作者/通讯作者发表SCI研究论文16篇。主持国家自然科学基金1项(81503097),中央高校基本科研业务费自然科学类重点项目1项(2016ZZD002)。参与国家自然科学面上项目1项,国家科技重大专项课题2项。申请国家发明专利4项,授权国家专利1项。


代表性研究论文:

1Libin Wei, Yuxin Zhou, Qinsheng Dai, Chen Qiao, Li Zhao, Hui Hui, Na Lu*,Qinglong Guo*. Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3 mediated deacetylation of cyclophilin D in breast carcinoma. Cell Death & Disease . 2013;18(4):e601 (IF2013=5.177)

2Kai Zhao, Yuxin Zhou, Chen Qiao, Ting Ni, Zhiyu Li, Xiaotang Wang, Qinglong Guo, Na Lu*, Libin Wei*. Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. Journal of Hematology & Oncology. 2015 Apr 23;8:41 (IF2015=6.262)

3Libin Wei, Yuxin Zhou, Chen Qiao, Ting Ni, Zhiyu Li,  Qidong You*, Qinglong Guo* , Na Lu*.Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. Cell Death & Disease.2015. Apr 9;6:e1714 (IF2015=5.378)

4Libin Wei, Yuxin Zhou, Jing Yao, Chen Qiao, Ting Ni, Ruichen Guo, Qinglong Guo* and Na Lu*.Lactate promotes PGE2 synthesis and gluconeogenesis in monocytes to benefit the growth of inflammation-associated colorectal tumor. Oncotarget. 2015 Jun 30;6(18):16198-214. (IF2015=5.008)

5Libin Wei1, Yuyuan Yao1, Kai Zhao, Yujie Huang, Yuxin Zhou, Li Zhao, Qinglong Guo,* and Na Lu*.Oroxylin A Inhibits Invasion and Migration Through Suppressing ERK/GSK-3b Signaling in Snail-Expressing Non-Small-Cell Lung Cancer Cells. Molecular Carcinogenesis, 2016 Dec;55(12):2121-2134. (IF2016=4.185)

6Lin Yang1, Yinan Yuan1, Chengyu Fu, Xuefen Xu, Jieying Zhou, Shuhao Wang, Lingyi Kong, Zhiyu Li, Qinglong Guo*, Libin Wei*. LZ-106, a novel analog of enoxacin, inducing apoptosis via activation of ROS-dependent DNA damage response in NSCLCs. Free Radical Biology and Medicine. 2016Jun; 95, 155–168. (IF2016=5.965)

7Ting Ni1, Zihao He1, Yuanyuan Dai, Jingyue Yao, Qinglong Guo*, and Libin Wei*.Oroxylin A suppresses the development and growth of colorectal cancer through reprogram of HIF1α-modulated fatty acid metabolism. Cell Death and Disease 2017 Jun 8;8(6):e2865  (IF2016=5.965)

8Libin Wei1, Yuanyuan Dai1, Yuxin Zhou, Zihao He, Jingyue Yao, Li Zhao, Qinglong Guo*,and Lin Yang*.Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression. Cell Death and Disease (2017) 8, e2944 (IF2016=5.965)


联系方式

地址:江苏省南京市鼓楼区童家巷24号中国药科大学科研大楼111114

邮箱:wlbiws_1986@aliyun.com