孙凌云(兼职导师)

发布者:陈洁洋发布时间:2018-09-30浏览次数:5946

    孙凌云,主任医师、博士、教授、博士生导师,南京大学医学院附属鼓楼医院副院长,风湿免疫科行政主任,南京大学风湿免疫研究所所长。现任国家干细胞专家委员会委员、中国医药学会干细胞质量控制和研究委员会副主任委员,中国抗衰老学会交叉委员会副主任委员,江苏风湿病学会主任委员。曾任全国风湿病学会副主任委员。在国际上首先开展异体间充质干细胞治疗红斑狼疮等自身免疫病,已完成968例,在国际大会发言40余次。在Cell Stem CellImmunityNat ImmunolNat MedJEMCell ReserchARD等国内外发表论文455篇,其中SCI论文135篇,主参编专著16部。Int J Rheum DisPathologie  Biologie副主编,Arthritis Res TherQJM编委。获江苏省科技进步一等奖、中华医学二等奖等。承担国家省部级科研项目22项。2015年获第七届国家卫生计生突出贡献中青年专家。江苏省医学杰出人才、江苏省中青年首席科学家、南京十大科技之星、南京科技功臣。2002国务院特殊津贴。


学习与工作经历

1987.9-1990.7    南京医科大学硕士研究生

1990.8-至今      南京鼓楼医院风湿科


1994.8-1995.11   意大利费拉拉大学进修

2003.9-2007.7    南京医科大学博士研究生

2004.2-2004.8    英国谢菲尔德大学进修


研究方向:

MSC治疗自身免疫病的基础和临床研究

自身免疫病发病机制研究


主持国家自然科学基金情况:

  1. 国家自然科学基金国际(地区)合作与交流项目MSC吞噬凋亡细胞调控Breg对红斑狼疮的治疗作用及机制研究817201080202018-2022-

  2. 国家自然科学基金(重大研究计划)原发性胆汁性肝硬化的免疫失调及MSCs干预作用的机制研究914421192015-2017

  3. 国家自然科学基金SLE骨髓MSCs异常表达CCL2调控B细胞的作用及机制研究812733042013-2016

  4. 国家自然科学基金致炎性间充质干细胞在类风湿关节炎中的作用研究812611303152012-2013

  5. 国家自然科学基金(国际合作与交流项目)MSCs诱导CD4T细胞凋亡上调Treg治疗SLE的机制研究811201080212012-2016

  6. 国家自然科学基金骨髓MScs抑制B细胞功能及其治疗MRL/Ipr狼疮鼠的机制309727362010-2012

  7. 国家自然科学基金骨髓间充质干细胞通过上调Treg细胞治疗MRL/lpr狼疮肾炎及其机制307720142008-2010


发表论文

一作/共同一作:

  1. Sun L(#)(*), Wang D, Liang J, Zhang H, Feng X, Wang H, Hua B, Liu B, Ye S, Hu X, Xu W, Zeng X, Hou Y, Gilkeson GS, Silver RM, Lu L, Shi S. Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. Arthritis Rheum. 2010;62:2467-2475.

  2. Sun L(#)(*), Akiyama K, Zhang H, Yamaza T, Hou Y, Zhao S, Xu T, Le A, Shi S. Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans. Stem Cells. 2009;27:1421-1432.

  3. Sun L(#)(*), Zhou K, Feng X, Zhang H, Ding X, Jin O, Lu L, Lau C, Hou Y, Fan L. Abnormal surface markers expression on bone marrow CD34+ cells and correlation with disease activity in patients with systemic lupus erythematosus. ClinRheumatol. 2007;26:2073-2079.

  4.  Chen C(#), Wang D, Moshaverinia A, Liu D, Kou X, Yu W, Yang R, Sun L(*), Shi S(*). Mesenchymal stem cell transplantation in tight-skin mice identifies miR-151-5p as a therapeutic target for systemic sclerosis. Cell Res. 2017;27:559-577.

  5.  Zhang Z(#), Feng R(#), Niu L, Huang S, Deng W, Shi B, Yao G, Chen W, Tang X, Gao X, Feng X(*), Sun L(*). Human Umbilical Cord Mesenchymal Stem Cells Inhibit T Follicular Helper Cell Expansion Through the Activation of iNOS in Lupus-Prone B6.MRL-Fas(lpr) Mice. Cell Transplant. 2017;26:1031-1042.

  6.  Liu C(#), Zhang H(#), Yao G, Hu Y, Qi J, Wang Y, Chen W, Tang X, Li W, Lu L, Gu L(*), Sun L(*). Characteristics of primary Sjogren's syndrome patients with IgG4 positive plasma cells infiltration in the labial salivary glands. ClinRheumatol. 2017;36:83-88.

  7.  FengX(#)(*), Chen W(#), Xiao L, Gu F, Huang J, Tsao BP, Sun L(*). Artesunate inhibits type I interferon-induced production of macrophage migration inhibitory factor in patients with systemic lupus erythematosus. Lupus. 2017;26:62-72.

  8.  Chu C(#), Zhou N(#), Zhang H, Dou X, Li M, Liu S, Zhu Y, Chen W, Chan Q, He J(*), Sun L(*), Zhou Z(*). Correlation between intravoxel incoherent motion MR parameters and MR nodular grade of parotid glands in patients with Sjogren's syndrome: A pilot study. Eur J Radiol. 2017;86:241-247.

  9.  Wang D(#), Niu L(#), Feng X, Yuan X, Zhao S, Zhang H, Liang J, Zhao C, Wang H, Hua B, Sun L(*). Long-term safety of umbilical cord mesenchymal stem cells transplantation for systemic lupus erythematosus: a 6-year follow-up study. ClinExp Med. 2017;17:333-340.

  10.  Ma X(#), Chen Z(#), Hu W, Guo Z, Wang Y, Kuwana M, Sun L(*). Clinical and serological features of patients with dermatomyositis complicated by spontaneous pneumomediastinum. ClinRheumatol. 2016;35:489-493.

  11.  Wang D(#), Chen H, Wang S, Zou Y, Li J, Pan J, Wang X, Ren T, Zhang Y, Chen Z, Feng X, Sun L(*). Thalidomide treatment in cutaneous lesions of systemic lupus erythematosus: a multicenter study in China. ClinRheumatol. 2016;35:1521-1527.

  12.  Chen J(#), Wang Q(#), Feng X, Zhang Z, Geng L, Xu T, Wang D, Sun L(*). Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria. Stem Cells Int. 2016;2016:4062789-42062789.

  13.  Huang S(#), Wang D(#), Gu F(#), Zhang Z, Deng W, Chen W, Tang X, Yao G, Feng X, Sun L(*). No significant effects of Poly(I:C) on human umbilical cord-derived mesenchymal stem cells in the treatment of B6.MRL-Fas(lpr) mice. Curr Res Transl Med. 2016;64:55-60.

  14.  FengX(#)(*), Pan W, Liu L, Wu M, Ding F, Hu H, Ding X, Wei H, Zou Y, Qian X, Wang M, Wu J, Tao J, Tan J, Da Z, Zhang M, Li J, Sun L(*), Jiangsu Lupus Collaborative G. Prognosis for Hospitalized Patients with Systemic Lupus Erythematosus in China: 5-Year Update of the Jiangsu Cohort. PLoS One. 2016;11:e0168619.

  15.  Deng W(#), Feng X, Li X, Wang D, Sun L(*). Hypoxia-inducible factor 1 in autoimmune diseases. Cell Immunol. 2016;303:7-15.

  16.  Liang J(#), Wang D, Dominique F, Sun L(*). Mesenchymal stem cells for treating autoimmune diseases: The Chinese experience from lab to clinics. Curr Res Transl Med. 2016;64:115-120.

  17.  Chu C(#), Zhou N, Zhang H, Dou X, Li M, Liu S, Zhu Y, Chen W, Chan Q, He J, Sun L(*), Zhou Z(*). Use of T1rhoMR imaging in Sjogren's syndrome with normal appearing parotid glands: Initial findings. J MagnReson Imaging. 2017;45:1005-1012.

  18.  Wang D(#),Sun L(*). Stem cell therapies for systemic lupus erythematosus: current progress and established evidence. Expert Rev ClinImmunol. 2015;11:763-769.

  19.  Wang H(#), Zhang M, Mao H, Cheng Z, Zhang Q, Jiang C, Sun C, Sun L(*). Serum neutrophil gelatinase-associated lipocalin and proinflammatory cytokines in pigs with septic versus non-septic acute kidney injury. IntUrolNephrol. 2015;47:413-420.

  20.  Chen Z(#), Hu W, Wang Y, Guo Z, Sun L(*), Kuwana M(*). Distinct profiles of myositis-specific autoantibodies in Chinese and Japanese patients with polymyositis/dermatomyositis. ClinRheumatol. 2015;34:1627-1631.

  21.  Sun Y(#), Deng W, Geng L, Zhang L, Liu R, Chen W, Yao G, Zhang H, Feng X, Gao X, Sun L(*). Mesenchymal stem cells from patients with rheumatoid arthritis display impaired function in inhibiting Th17 cells. J Immunol Res. 2015;2015:284215.

  22.  Yang X(#), Yao G, Chen W, Tang X, Feng X, Sun L(*). Exacerbation of lupus nephritis by high sodium chloride related to activation of SGK1 pathway. IntImmunopharmacol. 2015;29:568-573.

  23.  FengX(#)(*), Huang J, Liu Y, Xiao L, Wang D, Hua B, Tsao BP, Sun L(*). Identification of interferon-inducible genes as diagnostic biomarker for systemic lupus erythematosus. ClinRheumatol. 2015;34:71-79.

  24.  Wang D(#), Huang S, Yuan X, Liang J, Xu R, Yao G, Feng X, Sun L(*). The regulation of the Treg/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus. Cell MolImmunol. 2017;14:423-431.

  25.  Liang J(#), Sun L(*), Mesenchymal stem cells transplantation for systemic lupus erythematosus. Int J Rheum Dis, 2015.2.01, 18:2:164-171.

  26.  Deng W(#), Chen W, Zhang Z, Huang S, Kong W, Sun Y, Tang X, Yao G, Feng X, Chen W, Sun L(*). Mesenchymal stem cells promote CD206 expression and phagocytic activity of macrophages through IL-6 in systemic lupus erythematosus. ClinImmunol. 2015;161:209-216.

  27.  Chen H(#), Shi B(#), Feng X, Kong W, Chen W, Geng L, Chen J, Liu R, Li X, Chen W, Gao X, Sun L(*). Leptin and Neutrophil-Activating Peptide 2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway in Patients With Systemic Lupus Erythematosus. Arthritis Rheumatol. 2015;67:2383-2393.

  28.  Dong G(#), You M, Fan H, Ding L, Sun L(*), Hou Y(*). STS-1 promotes IFN-alpha induced autophagy by activating the JAK1-STAT1 signaling pathway in B cells. Eur J Immunol. 2015;45:2377-2388.

  29.  Chen C(#), Akiyama K(#), Wang D, Xu X, Li B, Moshaverinia A, Brombacher F, Sun L(*), Shi S(*). mTOR inhibition rescues osteopenia in mice with systemic sclerosis. J Exp Med. 2015;212:73-91.

  30.  Chen J(#), Feng X(#), Wang H, Hua B, Ding C, Liu B, Sun L(*). Discriminating infectious meningitis versus neuropsychiatric involvement in patients with systemic lupus erythematosus: a single-center experience. ClinRheumatol. 2015;34:365-369.

  31.  Liu R(#), Su D(#), Zhou M, Feng X, Li X, Sun L(*). Umbilical cord mesenchymal stem cells inhibit the differentiation of circulating T follicular helper cells in patients with primary Sjogren's syndrome through the secretion of indoleamine 2,3-dioxygenase. Rheumatology (Oxford). 2015;54:332-342.

  32.  GuF(#), Wang D(#), Zhang H, Feng X, Gilkeson GS, Shi S, Sun L(*). Allogeneic mesenchymal stem cell transplantation for lupus nephritis patients refractory to conventional therapy. ClinRheumatol. 2014;33:1611-1619.

  33.  FengX(#)(*), Zou Y, Pan W, Wang X, Wu M, Zhang M, Tao J, Zhang Y, Tan K, Li J, Chen Z, Ding X, Qian X, Da Z, Wang M, Sun L(*). Associations of clinical features and prognosis with age at disease onset in patients with systemic lupus erythematosus. Lupus. 2014;23:327-34.

  34.  FengX(#)(*), Gu F, Chen W, Liu Y, Wei H, Liu L, Yin S, Da Z, Sun L(*). Mizoribine versus mycophenolatemofetil or intravenous cyclophosphamide for induction treatment of active lupus nephritis. Chin Med J (Engl). 2014;127:3718-23.

  35.  GengL(#), Li X, Feng X, Zhang J, Wang D, Chen J, Liu R, Chen H, Sun L(*). Association of TNF-alpha with impaired migration capacity of mesenchymal stem cells in patients with systemic lupus erythematosus. J Immunol Res. 2014;2014:169082.

  36.  Fan H(#), Liu F, Dong G, Ren D, Xu Y, Dou J, Wang T, Sun L(*), Hou Y(*). Activation-induced necroptosis contributes to B-cell lymphopenia in active systemic lupus erythematosus. Cell Death Dis. 2014;5:e1416.

  37.  Su D(#), Liu R(#), Li X, Sun L(*). Possible novel biomarkers of organ involvement in systemic lupus erythematosus. ClinRheumatol. 2014;33:1025-1031.

  38.  Su D(#), Shen M(#), Gu B, Wang X, Wang D, Li X, Sun L(*). (99) Tc-methylene diphosphonate improves rheumatoid arthritis disease activity by increasing the frequency of peripheral gammadelta T cells and CD4(+) CD25(+) Foxp3(+) Tregs. Int J Rheum Dis. 2016;19:586-93.

  39.  Wang D(#), Li J, Zhang Y, Zhang M, Chen J, Li X, Hu X, Jiang S, Shi S, Sun L(*). Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study. Arthritis Res Ther. 2014;16:R79.

  40.  Wang D(#), Feng X, Lu L, Konkel JE, Zhang H, Chen Z, Li X, Gao X, Lu L, Shi S, Chen W, Sun L(*). A CD8 T cell/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus. Arthritis Rheumatol. 2014;66:2234-2245.

  41.  CheN(#), Li X(#), Zhang L, Liu R, Chen H, Gao X, Shi S, Chen W, Sun L(*). Impaired B cell inhibition by lupus bone marrow mesenchymal stem cells is caused by reduced CCL2 expression. J Immunol. 2014;193:5306-5314.

  42.  Shi D(#), Li X(#), Chen H, Che N, Zhou S, Lu Z, Shi S, Sun L(*). High level of reactive oxygen species impaired mesenchymal stem cell migration via overpolymerization of F-actin cytoskeleton in systemic lupus erythematosus. PatholBiol (Paris). 2014;62:382-390.

  43.  Deng W(#), Ren Y(#), Feng X(#), Yao G, Chen W, Sun Y, Wang H, Gao X, Sun L(*). Hypoxia inducible factor-1 alpha promotes mesangial cell proliferation in lupus nephritis. Am J Nephrol. 2014;40:507-515.

  44.  FengX(#)(*), Che N(#), Liu Y(#), Chen H, Wang D, Li X, Chen W, Ma X, Hua B, Gao X, Tsao BP, Sun L(*). Restored immunosuppressive effect of mesenchymal stem cells on B cells after olfactory 1/early B cell factor-associated zinc-finger protein down-regulation in patients with systemic lupus erythematosus. Arthritis Rheumatol. 2014;66:3413-3423.

  45.  Chen H(#), Zhou S(#), Su D, Lu L, Li X, Sun L(*). High-dose methylprednisolone pulse therapy upregulatedFcgammaRIIb expression on B cells in primary Sjogren's syndrome patients with thrombocytopenia. ClinRheumatol. 2013;32:1783-1790.

  46.  Ma X(#), Che N, Gu Z, Huang J, Wang D, Liang J, Hou Y, Gilkeson G, Lu L, Sun L(*). Allogenicmesenchymal stem cell transplantation ameliorates nephritis in lupus mice via inhibition of B-cell activation. Cell Transplant. 2013;22:2279-2290.

  47.  Wang D(#), Zhang H, Liang J, Li X, Feng X, Wang H, Hua B, Liu B, Lu L, Gilkeson GS, Silver RM, Chen W, Shi S, Sun L(*). Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experience. Cell Transplant. 2013;22:2267-2277.

  48.  Su D(#), Shen M, Li X, Sun L(*). Roles of gammadelta T cells in the pathogenesis of autoimmune diseases. ClinDevImmunol. 2013;2013:985753.

  49.  Chen Z(#), Cao M(#), Plana MN, Liang J, Cai H, Kuwana M(*), Sun L(*). Utility of anti-melanoma differentiation-associated gene 5 antibody measurement in identifying patients with dermatomyositis and a high risk for developing rapidly progressive interstitial lung disease: a review of the literature and a meta-analysis. Arthritis Care Res (Hoboken). 2013;65:1316-1324.

  50.  Tang Y(#), Xie H, Chen J, Geng L, Chen H, Li X, Hou Y, Lu L, Shi S, Zeng X, Sun L(*). Activated NF-kappaB in bone marrow mesenchymal stem cells from systemic lupus erythematosus patients inhibits osteogenic differentiation through downregulatingSmad signaling. Stem Cells Dev. 2013;22:668-678.

  51.  Li X(#), Wang D(#), Liang J, Zhang H, Sun L(*). Mesenchymal SCT ameliorates refractory cytopenia in patients with systemic lupus erythematosus. Bone Marrow Transplant. 2013;48:544-550.

  52.  Akiyama K(#), Chen C(#), Wang D(#), Xu X, Qu C, Yamaza T, Cai T, Chen W, Sun L(*), Shi S(*). Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis. Cell Stem Cell. 2012;10:544-555.

  53.  CheN(#), Li X(#), Zhou S, Liu R, Shi D, Lu L, Sun L(*). Umbilical cord mesenchymal stem cells suppress B-cell proliferation and differentiation. Cell Immunol. 2012;274:46-53.

  54.  Liang J(#), Zhang H, Wang D, Feng X, Wang H, Hua B, Liu B, Sun L(*). Allogeneic mesenchymal stem cell transplantation in seven patients with refractory inflammatory bowel disease. Gut. 2012;61:468-469.

  55.  GuF(#), Molano I, Ruiz P, Sun L(*), Gilkeson GS(*). Differential effect of allogeneic versus syngeneic mesenchymal stem cell transplantation in MRL/lpr and (NZB/NZW)F1 mice. ClinImmunol. 2012;145:142-152.

  56.  Liu R(#), Wu Q, Su D, Che N, Chen H, Geng L, Chen J, Chen W, Li X(*), Sun L(*). A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis. Arthritis Res Ther. 2012;14:R255.

  57.  FengX(#)(*), Wang D(#), Chen J, Lu L, Hua B, Li X, Tsao BP, Sun L(*). Inhibition of aberrant circulating Tfh cell proportions by corticosteroids in patients with systemic lupus erythematosus. PLoS One. 2012;7:e51982.

  58.  Su D(#), Lu Z, Shen M, Li X, Sun L(*). Roles of pro- and anti-inflammatory cytokines in the pathogenesis of SLE. J Biomed Biotechnol. 2012;2012:347141.

  59.  Li X(#), Liu L(#), Meng D(#), Wang D, Zhang J, Shi D, Liu H, Xu H, Lu L(*), Sun L(*). Enhanced apoptosis and senescence of bone-marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Stem Cells Dev. 2012;21:2387-2394.

  60.  Shi D(#), Wang D(#), Li X, Zhang H, Che N, Lu Z, Sun L(*). Allogeneic transplantation of umbilical cord-derived mesenchymal stem cells for diffuse alveolar hemorrhage in systemic lupus erythematosus. ClinRheumatol. 2012;31:841-846.

  61.  Wang D(#), Akiyama K(#), Zhang H, Yamaza T, Li X, Feng X, Wang H, Hua B, Liu B, Xu H, Chen W, Shi S(*), Sun L(*). Double allogenicmesenchymal stem cells transplantations could not enhance therapeutic effect compared with single transplantation in systemic lupus erythematosus. ClinDevImmunol. 2012;2012:273291.

  62.  Liang J(#), Li X(#), Zhang H, Wang D, Feng X, Wang H, Hua B, Liu B, Sun L(*). Allogeneic mesenchymal stem cells transplantation in patients with refractory RA. ClinRheumatol. 2012;31:157-161.

  63.  Wang D(#), Zhang H, Liang J, Gu Z, Ma X, Huang J, Lin J, Hou Y, Lu L, Sun L(*). Effect of allogeneic bone marrow-derived mesenchymal stem cells transplantation in a polyI:C-induced primary biliary cirrhosis mouse model. ClinExp Med. 2011;11:25-32.

  64.  Wang D(#), Zhang H, Cao M, Tang Y, Liang J, Feng X, Wang H, Hua B, Liu B, Sun L(*). Efficacy of allogeneic mesenchymal stem cell transplantation in patients with drug-resistant polymyositis and dermatomyositis. Ann Rheum Dis. 2011;70:1285-1288.

  65.  Zhang H(#), Zeng X, Sun L(*). Allogenic bone-marrow-derived mesenchymal stem cells transplantation as a novel therapy for systemic lupus erythematosus. Expert OpinBiolTher. 2010;10:701-709.

  66.  Liang J(#), Zhang H(#), Hua B, Wang H, Lu L, Shi S, Hou Y, Zeng X, Gilkeson GS(*), Sun L(*). Allogenicmesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Ann Rheum Dis. 2010;69:1423-1429.

  67.  FengX(#)(*), Li R(#), Huang J, Zhang H, Zhu L, Hua B, Tsao BP, Sun L(*). Olf1/EBF associated zinc finger protein interfered with antinuclear antibody production in patients with systemic lupus erythematosus. Arthritis Res Ther. 2010;12:R59.

  68.  Liang J(#), Gu F, Wang H, Hua B, Hou Y, Shi S, Lu L, Sun L(*). Mesenchymal stem cell transplantation for diffuse alveolar hemorrhage in SLE. Nat Rev Rheumatol. 2010;6:486-489.

  69.  GuZ(#), Akiyama K(#), Ma X, Zhang H, Feng X, Yao G, Hou Y, Lu L, Gilkeson GS, Silver RM, Zeng X, Shi S(*), Sun L(*). Transplantation of umbilical cord mesenchymal stem cells alleviates lupus nephritis in MRL/lpr mice. Lupus. 2010;19:1502-1514.

  70.  Ma L(#), Zhao G, Hua C, Li X, Zhao X, Sun L(*), Hou Y(*). Down-regulation of TLR9 expression affects the maturation and function of murine bone marrow-derived dendritic cells induced by CpG. Cell MolImmunol. 2009;6:199-205.

  71.  Jin O(#), Zhang H(#), Gu Z, Zhao S, Xu T, Zhou K, Jiang B, Wang J, Zeng X, Sun L(*). A pilot study of the therapeutic efficacy and mechanism of artesunate in the MRL/lpr murine model of systemic lupus erythematosus. Cell MolImmunol. 2009;6:461-467.

  72.  Liang J(#), Zhang H, Hua B, Wang H, Wang J, Han Z, Sun L(*). Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosis. MultScler. 2009;15:644-646.


获科技奖励

  2000南京市科技进步奖,三等奖,排名第一

  2002南京市科技进步奖,二等奖,排名第一

  2007 江苏省科技进步奖,三等奖,排名第一

  2009江苏省新技术引进奖,特等奖,排名第一

  2009江苏省科技进步奖,二等奖,排名第一

  2009南京市科技进步奖,一等奖,排名第一

  2013江苏省医学奖,一等奖,排名第一

  2013 中华医学奖,二等奖,排名第一

  2013江苏省科技进步奖,一等奖,排名第一

  2013 南京市科技进步奖,一等奖,排名第一

  2014教育部高等学校科技奖进步奖,二等奖,排名第一

  2015 南京科技进步奖,三等奖,排名第一


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