杨林

发布者:基础医学发布时间:2020-07-27浏览次数:10


    杨林,男,副教授,硕士研究生导师。20133月毕业于东南大学,获理学博士学位。同年7月加入我校生理学系暨江苏省肿瘤发生与干预重点实验室。201812月至20207月,美国希望城国家医疗中心访问学者。研究方向为肿瘤药理学,主要关注1)基于DNA损伤修复的肿瘤发生机制及药物干预的体内外研究;2)天然产物及其衍生物抗肿瘤作用的靶点与机制研究。近年来,先后主持国家自然科学基金,江苏省自然科学基金,中央高校基本科研业务项目等课题,参与多项国家自然科学基金、国家科技重大专项及抗肿瘤新药的研发工作。



代表性论文:

  1. Yang, L., Meng, F., Ma, D., Xie, W., and Fang, M. (2013). Bridging Decapentaplegic and Wingless signaling in Drosophila wings through repression of naked cuticle by Brinker. Development 140, 413-422. (IF=6.632)

  2. Yang, L.#, Yuan, Y.#, Fu, C., Xu, X., Zhou, J., Wang, S., Kong, L., Li, Z., Guo, Q., and Wei, L. (2016). LZ-106, a novel analog of enoxacin, inducing apoptosis via activation of ROS-dependent DNA damage response in NSCLCs. Free Radic Biol Med 95, 155-168. (IF=5.606)

  3. Wei L, Dai Y, Zhou Y, He Z, Yao J, Zhao L, Guo Q and Yang L (2017) Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression. Cell Death Dis8(7): e2944. (IF=5.638)

  4. Yang L#, He Z#, Yao J, Tan R, Zhu Y, Li Z, Guo Q and Wei L (2018) Regulation of AMPK-related glycolipid metabolism imbalances redox homeostasis and inhibits anchorage independent growth in human breast cancer cells. Redox Biol17: 180-191. (IF=7.793)

  5. Yang L, Zhou J, Meng F, Fu C, Zou X, Liu J, Zhang C, Tan R, Li Z, Guo Q and Wei L (2019) G1 phase cell cycle arrest in NSCLC in response to LZ-106, an analog of enoxacin, is orchestrated through ROS overproduction in a P53-dependent manner. Carcinogenesis 40, 131-144.(IF=4.603)

联系方式:lin_yang@cpu.edu.cn; yanglin.seu@gmail.com