个人简介：
顾丰 (Harvest F. Gu)， 祖籍中国江苏，瑞典藉华人，现任中国药科大学基础医学和临床药学学院分子医学研究室教授。在瑞典斯德哥尔摩卡罗琳斯卡医学院分子医学系从事科研和教学工作近30年，任糖尿病和糖尿病肾病遗传学和表观遗传学首席科学家，博士生导师，助理教授、副教授和研究员。已发表SCI论文200余篇，参编或主编专著6部，专利3项。在国内曾任中国医学科学院北京协和医学院、重庆医科大学、浙江大学医学院、山东大学省立医院、南京医科大学等单位客座或讲席教授，国家自然科学基金重大项目和面上项目评委，美国糖尿病协会以及英国、新加坡和香港等科研项目评委，人类基因组组织、欧洲糖尿病协会、美国糖尿病协会、欧洲糖尿病肾病学会、瑞典糖尿病协会和瑞典教师协会成员，瑞典中华医学会首届副会长兼学术委员会主任，侨联海外顾问、专业委员会特聘专家等。
学科领域：
分子医学（Molecular Medicine）
发表论文（2018-2022）
Lian Z, Wu Z, Gu R, Wang Y, Wu C, Cheng Z, He M, Wang Y, Cheng Y*, Gu HF*. Evaluation of Cardiovascular Toxicity of Folic Acid and 6S-5-Methyltetrahydrofolate-Calcium in Early Embryonic Development. Cells. 2022 Dec 7;11(24):3946.
Shi R, Tao Y, Tang H, Wu C, Fei J, Ge H, Gu HF*, Wu J*. Abelmoschus Manihot ameliorates the levels of circulating metabolites in diabetic nephropathy by modulating gut microbiota in non-obese diabetes mice. Microb Biotechnol. 2022 Dec 30. doi: 10.1111/1751-7915.14200.
Wu C, Fei J, Xu Q, Tao Y, Zhou Z., Wang Y, Wu J, Gu HF*. Interaction between Plasma Metabolomics and Intestinal Microbiome in db/db Mouse, an Animal Model for Study of Type 2 Diabetes and Diabetic Kidney Disease. Metabolites. 2022, 12,775.
Wu C, Tao Y, Li N, Fei J, Wang Y, Wu J*, Gu HF*. Prediction of cellular targets in diabetic kidney diseases with single-cell transcriptomic analysis of db/db mouse kidneys.J Cell Commun Signal. 2022 Jul 9.
Chen X, Liu C, Yang S, Yang Y, Chen Y, Zhao X, Zhu W, Zhao Q, Ni C, Huang X, Yan W, Shen C*, Gu HF*. Gender Specificity and Local Socioeconomic Influence on Association of GHR fl/d3 Polymorphism with Growth and Metabolism in Children and Adolescents. Front Pediatr. 2022 Mar 23;10:546080.
Cheng Z, Gu R, Lian Z, Gu HF*. Evaluation of the association between maternal folic acid supplementation and the risk of congenital heart disease: a systematic review and meta-analysis. Nutr J. 2022 Mar 26;21(1):20.
Zhao J, Tostivint I, Xu L, Huang J, Gambotti L, Boffa JJ, Yang M, Wang L, Sun Z, Chen X, Liou-Schischmanoff A, Baumelou A, Ma T, Lu G, Li L, Chen D, Piéroni L, Liu B, Qin X, He W, Wang Y, Gu HF*, Sun W*. Efficacy of Combined Abelmoschus manihot and Irbesartan for Reduction of Albuminuria in Patients With Type 2 Diabetes and Diabetic Kidney Disease: A Multicenter Randomized Double-Blind Parallel Controlled Clinical Trial. Diabetes Care. 2022 Jul 7;45(7):e113-e115.
You Q, Shen Y, Wu Y, Li Y, Liu C, Huang F, Gu HF*, Wu J*. Neutrophil Extracellular Traps Caused by Gut Leakage Trigger the Autoimmune Response in Nonobese Diabetic Mice. Front Immunol. 2022 Jan 17;12:711423.
Dong H, Feng C, Cai X, Hao Y, Gu X, Cai L, Wu S, Chen J, Liu Z, Xie W, Lu X, Qian H, Liu Y, Cao Y, Zhu J, Xu J, Zhou Y, Ma S, Yang S, Shi Y, Yu H, Shi M, Wang Y, Gu HF, Fan L, Wu L. 7-Methoxyisoflavone ameliorates atopic dermatitis symptoms by regulating multiple signaling pathways and reducing chemokine production. Sci Rep. 2022 May 24;12(1):8760.
Li N, Gu HF*. Genetic and Biological Effects of SLC12A3, a Sodium-Chloride Cotransporter, in Gitelman Syndrome and Diabetic Kidney Disease. Front Genet. 2022 May 3;13:799224.
Sun J, Ji J, Wang Y, Gu HF*. Association of the Haze and Diabetes in China. Curr Diabetes Rev. 2021;17(1):11-20.
He Y, Zhang C, Luo Y, Chen J, Yang M, Li L, Gu HF, Yang G, Zhang X. Hypothalamic BMP9 suppresses glucose production by central PI3K/Akt/mTOR pathway. J Endocrinol. 2021 Feb;248(2):221-235.
Wu L, Wang Y, Wang X, Liao J, Dong H, Cai X, Wang Y, Gu HF*. Evaluation of Colocasia esculenta Schott in anti-cancerous properties with proximity extension assays. Food Nutr Res. 2021 Oct 4;65.
Zhang X, Guan T, Yang B, Chi Z, Wan Q, Gu HF*. SLC30A7 has anti-oxidant stress effects in high glucose-induced apoptosis via the NFE2L2/HMOX1 signal transduction pathway. Diabetes Res Clin Pract. 2021 Feb;172:108445.
Li N, Tang H, Wu L, Ge H, Wang Y, Yu H, Zhang X, Ma J, Gu HF*. Chemical constituents, clinical efficacy and molecular mechanisms of the ethanol extract of Abelmoschus manihot flowers in treatment of kidney diseases. Phytother Res. 2021 Jan;35(1):198-206. (Journal cover article)
Liu X, Zhang X, Cai X, Dong J, Chi Y, Chi Z, Gu HF*. Effects of Curcumin on High Glucose-Induced Epithelial-to-Mesenchymal Transition in Renal Tubular Epithelial Cells Through the TLR4-NF-κB Signaling Pathway. Diabetes Metab Syndr Obes. 2021 Mar 2;14:929-940.
de Borst MH, Gu HF. Editorial: Genetics of Kidney Diseases. Front Genet. 2020 Apr 3;11:305.
Zhang X, Seman NA, Falhammar H, Brismar K, Gu HF*. Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney Disease. J Diabetes Res. 2020 Jun 12;2020:8305460.
Zhang X, Guan T, Yang B, Gu HF*, Chi Z*. Effects of ZnT8 on epithelial-to-mesenchymal transition and tubulointerstitial fibrosis in diabetic kidney disease. Cell Death Dis. 2020 Jul 17;11(7):544.
Su J, Wang H, Tian Y, Hu H, Gu W, Zhang T, Li M, Shen C*, Gu HF*. Impact of physical exercise intervention and PPARγ genetic polymorphisms on cardio-metabolic parameters among a Chinese youth population. BMJ Open Sport Exerc Med. 2020 Apr 1;6(1):e000681.
Wang Y, Wang C, Cai X, Mou C, Cui X, Zhang Y, Ge F, Dong H, Hao Y, Cai L, Wu S, Feng C, Chen J, Li J, Xu W, Fan L, Xie W, Tong Y, Gu HF, Wu L. IL-21 Stimulates the expression and activation of cell cycle regulators and promotes cell proliferation in EBV-positive diffuse large B cell lymphoma. Sci Rep. 2020 Jul 23;10(1):12326.
Gu HF*. Development and application of pyrosequencing technology焦磷酸光化测序技术的发展和应用Chinese Bulletin of Life Science《生命科学》2020年5月第32卷第5期515-521页。
Zhang C, Luo X, Chen J, Zhou B, Yang M, Liu R, Liu D, Gu HF, Zhu Z, Zheng H, Li L, Yang G. Osteoprotegerin Promotes Liver Steatosis by Targeting the ERK-PPAR-γ-CD36 Pathway. Diabetes. 2019 Oct;68(10):1902-1914.
Salem RM, Todd JN, Sandholm N, …… Gu HF,…. SUMMIT Consortium, DCCT/EDIC Research Group, GENIE Consortium. Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen. J Am Soc Nephrol. 2019 Oct;30(10):2000-2016.
Ekberg NR, Eliasson S, Li YW, Zheng X, Chatzidionysiou K, Falhammar H, Gu HF, Catrina SB. Protective Effect of the HIF-1A Pro582Ser Polymorphism on Severe Diabetic Retinopathy. J Diabetes Res. 2019 May 12;2019:2936962.
Zhang X, Gu HF*, Frystyk J, Efendic S, Brismar K, Thorell A. Analyses of IGFBP2 DNA methylation and mRNA expression in visceral and subcutaneous adipose tissues of obese subjects. Growth Horm IGF Res. 2019 Apr;45:31-36.
Wu T, Zhang Q, Wu S, Hu W, Zhou T, Li K, Liu D, Gu HF, Zheng H, Zhu Z, Li L, Yang G. CILP-2 is a novel secreted protein and associated with insulin resistance. J Mol Cell Biol. 2019 Dec 19;11(12):1083-1094.
You Q, He DM, Shu GF, Cao B, Xia YQ, Xing Y, Ni M, Chen JF, Shi SL, Gu HF, Liu Y, Wu J. Increased formation of neutrophil extracellular traps is associated with gut leakage in patients with type 1 but not type 2 diabetes. J Diabetes. 2019 Aug;11(8):665-673.
Yang P, Liang Y, Luo Y, Li Z, Wen Y, Shen J, Li R, Zheng H, Gu HF*, Xia N*. Liraglutide ameliorates nonalcoholic fatty liver disease in diabetic mice via the IRS2/PI3K/Akt signaling pathway. Diabetes Metab Syndr Obes. 2019 Jul 4;12:1013-1021.
Zhang X, Guan T, Yang B, Chi Z, Wan Q, Gu HF*. Protective effect of berberine on high glucose and hypoxia-induced apoptosis via the modulation of HIF-1α in renal tubular epithelial cells. Am J Transl Res. 2019 Feb 15;11(2):669-682.
Lin Y, Liang Z, He L, Yang M, Liu D, Gu HF, Liu H, Zhu Z, Zheng H, Li L, Yang G. Gut ghrelin regulates hepatic glucose production and insulin signaling via a gut-brain-liver pathway. Cell Commun Signal. 2019 Jan 25;17(1):8.
Wang Y, Wang C, Zhang X, Gu HF, Wu L. Common Drugs for Stabilization of Renal Function in the Progression of Diabetic Nephropathy and Their Relations with Hypertension Therapy. Curr Diabetes Rev. 2018;14(2):149-161.
Wei Q, Zhou B, Yang G, Hu W, Zhang L, Liu R, Li M, Wang K, Gu HF, Guan Y, Zhu Z, Zheng H, Peng J, Li L. JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c -dependent mechanism. Cell Death Dis. 2018 Aug 28;9(9):859.
Zhang X, Lian X, Liang D, Zhang L, Liu S, Yang L, Chi ZH, Gu HF*. Protective Effect of Znt7 on High Glucose-Induced Epithelial-to-Mesenchymal Transition in Renal Tubular Epithelial Cells. Kidney Blood Press Res. 2018;43(2):500-512.
Hage C, Bjerre M, Frystyk J, Gu HF, Brismar K, Donal E, Daubert JC, Linde C, Lund LH. Comparison of Prognostic Usefulness of Serum Insulin-Like Growth Factor-Binding Protein 7 in Patients with Heart Failure and Preserved Versus Reduced Left Ventricular Ejection Fraction. Am J Cardiol. 2018 Jun 15;121(12):1558-1566.
Malipatil N, Lunt M, Narayanan RP, Siddals K, Cortés Moreno GY, Gibson MJ, Gu HF, Heald AH, Donn RP. Assessment of global long interspersed nucleotide element-1 (LINE-1) DNA methylation in a longitudinal cohort of type 2 diabetes mellitus (T2DM) individuals. Int J Clin Pract. 2018 Oct 21:e13270.
Fang X, Zhang T, Yang M, Li L, Zhang C, Hu W, Fan X, Liu H, Zhu Z, Liu D, Zheng H, Gu HF, Liu R, Yang G. High Circulating Alarin Levels Are Associated with Presence of Metabolic Syndrome. Cell Physiol Biochem. 2018;51(5):2041-2051.
Villela-Torres ML, Higareda-Mendoza AE, Gómez-García A, Alvarez-Paredes AR, García-López E, Stenvikel P, Gu HF, Rashid-Qureshi A, Lindholm B, Alvarez-Aguilar C. Copeptin Plasma Levels are Associated with Decline of Renal Function in Patients with Type 2 Diabetes Mellitus. Arch Med Res. 2018 Jan;49(1):36-43
Zhang X, Guan T, Yang B, Chi Z, Wang ZY, Gu HF*. A novel role for zinc transporter 8 in the facilitation of zinc accumulation and regulation of testosterone synthesis in Leydig cells of human and mouse testicles. Metabolism. 2018 Nov;88:40-50.
出版专著：
Gu HF. Epigenetic Studies of Diabetic Nephropathy in “Handbookof Nutrition, Diet, and Epigenetics edited by Patel VB and Preedy VR, (Hard copy) published by Nature Springer, UK 2019.
Gu HF. Zinc Deficiency and Epigenetics in “Handbook of Famine, Starvation, and Nutrient Deprivation”edited by Patel VB and Preedy VR, (Hard copy) published by Nature Springer, UK 2019.
Gu HF. Genetic and epigenetic study of diabetic kidney disease in “Genetics of Kidney Diseases” edited by Gu HF and de Borst MH, (e-Book) by Frontiers in Genetics, Swiss 2020.
研究生课程：
Molecular Medicine and its Methodologies (MMM)
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