薛红教授， 1983年毕业于上海第二军医大学军医系，1986年获第二军医大学病理生理学硕士，1988年赴加拿大多伦多大学生物化学系担任访问学者，1989年至1992年于多伦多大学医学院医学科学研究所获得博士学位，期间于法国国家科学院酶学研究所担任访问学者，1993至1994年于英国格拉斯哥大学遗传学系担任博士后研究员，1995年至今于香港科技大学生物化学系及生命科学部先后担任助理教授、副教授、教授及应用基因组中心主任，并兼任国际肿瘤基因组项目地区负责人、国家自然科学基金委医学部及香港健康与医学研究基金评委。2018年起，担任中国药科大学基础医学与临床药学学院兼职教授，及肿瘤基因组中心主任。作为主要负责人已完成多项由香港特区政府大学教育资助委员会及创新科技署所资助的研究课题，参与了973、863、十三五重大新药创制专项，以及多个国家自然科学基金委面上和重点项目。并获得国家教育部科学技术奖，及香港裘槎基金会资深研究员等奖项。已发表论文200余篇，其中Scopus数据库收录的134篇被引用11715次，H指数32。
主要研究兴趣为人类复杂疾病，包括肿瘤及精神神经疾患的基因组学基础及生物进化规律；并深入探讨以遗传学及表观遗传学证据为基础的早期诊断方法，及以分子靶标为基础的中药天然药的研发。主要研究成果包括（1）在国际上首先发现并功能验证了一个重要的精神分裂症相关基因GABRB2；（2）创建了以转座子为基础的人类基因组序列及结构的扫描技术，并用于肿瘤基因组学研究，从而发现了广泛存在的间隙性杂合子缺失现象，提示以姐妹染色体间基因转换为机制的DNA双链断裂修复，在肿瘤发生发展中的重要作用；（3）率先从中草药中发现了具有中枢神经系统活性的黄酮类化合物，并且进行了深入的药效及药理学研究，特别是针对甲型伽马氨基丁酸受体的结合活性及构效关系进行了较为系统的研究，其中单篇论文引用率超过200次。
分类代表论文：
基因组学
Shui-Ying Tsang; Tanveer Ahmad; Flora Mat; Cunyou Zhao; Shifu Xiao; Kun Xia; Hong Xue (2016) Variation of global DNA methylation levels with age and in autistic children. BMC Human Genomics10 (1): 31
Siu-Kin Ng, Taobo Hu, Xi Long, Cheuk-Hin Chan, Shui-Ying Tsang and Hong Xue (2016) Feature co-localization landscape of the human genome. Scientific Reports 6:20650
Yogesh Kumar, Jianfeng Yang, Taobo Hu, Lei Chen, Zhi Xu, Lin Xu, Xiao-Xia Hu, Jian-Min Wang, Yi Li, Wai-Sang Poon, Weiqing Wan, Liwei Zhang, Wai-Kin Mat, Frank W. Pun, Peggy Lee, Timothy H. Y. Cheong, Xiaofan Ding, Jin-Fei Chen, Shao Li, Hong-Yang Wang, and Hong Xue (2015) Massive interstitial loss-of-heterozygosity as evidence for cancer being a disease of the DNA-damage response. BMC Medical Genomics 8:42
Jian-Feng Yang, Xiao-Fan Ding, Lei Chen, Wai-Kin Mat, Michelle Zhi Xu, Jin-Fei Chen, Jian-Min Wang, Lin Xu, Wai-Sang Poon, Ava Kwong, Gilberto Ka-Kit Leung, Tze-Ching Tan, Chi-Hung Yu, Yue-Bin Ke, Xin-Yun Xu, Xiao-Yan Ke, Ronald C. W. Ma, Juliana C. N. Chan, Wei-Qing Wan, Li-Wei Zhang, Yogesh Kumar, Shui-Ying Tsang, Shao Li, Hong-Yang Wang and Hong Xue (2014) Copy number variation analysis based on AluScan sequences. Journal of Clinical Bioinformatics 4:15
Cunyou Zhao and Hong Xue (2012) A simple method for high-throughput quantification of genome-wide DNA methylation by fluorescence polarization. Epigenetics7:335-339
Lingling Mei, Xiaofan Ding, Shui-Ying Tsang, Frank W. Pun, Siu-Kin Ng, Cunyou Zhao, Dezhi Li, Weiqing Wan, Gilberto Ka Kit Leung, Ho-Keung Ng, Liwei Zhang and Hong Xue (2011) AluScan: a method for genome-wide scanning of sequence variations in the human genome. BMC Genomics 12:564
The International Cancer Genome Consortium (2010) International network of cancer genome projects. Nature 464(7291):993-998
The International HapMap Consortium. (2007) A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851-861
Siu-Kin Ng and Hong Xue (2006) Alu-Associated Enhancement of Single Nucleotide Polymorphisms in the Human Genome. Gene 368: 110-116
The International HapMap Consortium (2005) A Haplotype Map of the Human Genome. Nature 437:1299-1320
精神分裂症基因
Rigil K. Yeung, Zheng-Hua Xiang, Shui-Ying Tsang, Rui Li, Timothy Y. C. Ho,Qi Li, Chok-King Hui, Pak-Chung Sham, Ming-Qi Qiao and Hong Xue (2018) Gabrb2 knockout mice displayed schizophrenia-like and comorbid phenotypes with interneuron-astrocyte-microglia dysregulation. Translational Psychiatry (In press)
Yung Su Kim, Mei Yang,Wai-Kin Mat, Shui-Ying Tsang, Zhonghua Su, Xianfei Jiang, Siu-Kin Ng, Siyu Liu, Taobo Hu, Frank Pun, Yanhui Liao, Jinsong Tang, Xiaogang Chen, Wei Hao and Hong Xue (2015) GABRB2 haplotype association with heroin dependence in Chinese population.PLoS ONE 10 (11): e0142049
Shui Ying Tsang, Songfa Zhong, Lingling Mei, Jianhuan Chen, Siu-Kin Ng, Frank W. Pun, Cunyou Zhao, Robin Chark, Jianhua Guo, Yunlong Tan, Lijun Li, Chuanyue Wang, Soo Hong Chew and Hong Xue (2013) Social cognitive role of schizophrenia candidate gene GABRB2. PLoS ONE 8 (4): e62322
Cunyou Zhao, Feng Wang, Frank W. Pun, Lingling Mei, Lihuan Ren, Zhiliang Yu, Siu-Kin Ng, Jianhuan Chen, Shui-Ying Tsang and Hong Xue (2012) Epigenetic regulations on GABRB2 isoform expressions: developmental variations and disruptions in psychotic disorders. Schizophrenia Research 134:260-266
F W Pun, C Zhao, W-S Lo, S-K Ng, S-Y Tsang, V Nimgaonkar, W S Chung, G S Ungvari and Hong Xue(2011) Imprinting in the schizophrenia candidate gene GABRB2 encoding GABAA receptor 2 subunit. Molecular Psychiatry16: 557-568
Siu-Kin Ng, Wing-Sze Lo, Frank W. Pun, Cunyou Zhao, Zhiliang Yu, Jianhuan Chen, Ka-Lok Tong, Zhiwen Xu, Shui-Ying Tsang, Qiang Yang, Weichuan Yu, Vishwajit Nimgaonkar, Gerald Stöber, Mutsuo Harano, and Hong Xue (2010) A recombination hotspot in a schizophrenia-associated region of GABRB2. PLoS ONE 5(3): e9547
Cunyou Zhao, Zhiwen Xu, Feng Wang, Jianhuan Chen, Siu-Kin Ng, Pak-Wing Wong, Zhiliang Yu, Frank W. Pun, Lihuan Ren, Wing-Sze Lo, Shui-Ying Tsang, and Hong Xue (2009) Alternative-splicing in the Exon-10 region of GABAA receptor β2 subunit gene: relationships between novel isoforms and psychotic disorders. PLoS ONE 4(9): e6977
Wing-Sze Lo, Zhiwen Xu, Zhiliang Yu, Frank W. Pun, Siu-Kin Ng, Jianhuan Chen, Ka-Lok Tong, Cunyou Zhao, Xiaojing Xu, Shui-Ying Tsang, Mutsuo Harano, Gerald Stöber, Vishwajit L. Nimgaonkar and Hong Xue (2007) Positive selection within the schizophrenia-associated GABAA receptor β2 gene. PLoS ONE 2(5): e462
Wing-Sze Lo, Mutsuo Harano, Micha Gawlik, Zhiliang Yu, Jianhuan Chen, Frank Wing Pun, Ka-Lok Tong, Cunyou Zhao, Siu-Kin Ng, Shui-Ying Tsang, Naohisa Uchimura, Gerald Stoeber and Hong Xue (2007) GABRB2 association with schizophrenia: commonalities and differences between ethnic groups and clinical subtypes. Biological Psychiatry 61:653-660
Zhiliang Yu, Jianhuan Chen, Haifeng Shi, Gerald Stoeber, Shui Ying Tsang and Hong Xue (2006) Association of SNPs in GABRB2 with schizophrenia in German population: application of two-base extension genotyping. Clinical Biochemistry 39 (3): 210-218
Cunyou Zhao, Zhiwen Xu, Jianhuan Chen, Zhiliang Yu, Ka-Lok Tong, Wing Sze, Cario Lo, Frank Wing Pun, Siu-Kin Ng, Shui-Ying Tsang, and Hong Xue (2006) Two isoforms of GABAA receptor β2 subunit with different electrophysiological properties: differential expression and genotypical correlations in schizophrenia. Molecular Psychiatry 11:1092-1105
Wing-Sze Lo, Ching-Fun Lau, Zhenyu Xuan, Anthony Chun-Fung Chan, Guo-Yin Feng, Lin He, Zhong-Chang Cao, Hua Liu, Qing-Ming Luan, and Hong Xue (2004) Association of SNPs and haplotypes in GABAA receptor 2 gene with schizophrenia. Molecular Psychiatry 9 (6): 603-608
中药天然药
Rui Li, Wing Man Chan, Yiu Cheong Ho, Rigil Ken Yeung and Hong Xue (2017) Anti-aging and anxiolytic effects of combinatory formulas based on four medicinal herbs. Evidence-based Complementary and Alternative Medicine 2017: ID 4624069
Ho, T. Y. C. and Xue H (2016) Dispersed mobile-phase countercurrent chromatography. Separations 3:32
Ho, T. Y. C. and Xue H (2016) Effects of 4 Flavonoids from Scutellaria Baicalensis on Different Cancer Cell Lines. Modernization of Traditional Chinese Medicine and Material Medica18 (11):1845-1854
Ren, Lihuan, Feng Wang, Zhiwen Xu, Wing Man Chan, Cunyou Zhao and Hong Xue (2010) GABAA receptor subtype selectivity underlying anxiolytic effect of 6-hydroxyflavone. Biochemical Pharmacology79 (9):1337-1344
Wang, Feng, Zhiwen Xu,Lihuan Ren, Shui Ying Tsang and Hong Xue (2008) GABAA receptor subtype selectivity underlying selective anxiolytic effect of baicalin. Neuropharmacology 55:1231-1237
Zhiwen Xu, Feng Wang, Shui Ying Tsang, Kwan Hang Ho, Hui Zheng, Chun Tak Yuen, Chun Yin Chow and Hong Xue (2006) Anxiolytic-like effect of baicalin and its additivity with other anxiolytics. Planta Medica 72: 189-192
Man Chun Tai, Shui Ying Tsang, Lawrence Y.F. Chang and Hong Xue (2005) Therapeutic potentials of wogonin: a naturally occurring flavonoid. CNS Drug Reviews 11 (2): 141 - 50
Feng Wang, Michael Shing Yan Huen, Shui Ying Tsang and Hong Xue (2005) Neuroactive flavonoids interacting with GABAA receptor complex. Current Drug Targets – CNS & Neurological disorders 4:575-585
Michael S.Y. Huen, Justin W.C. Leung, Wah Ng, W.S. Lui, Michelle N.S. Chan, J. Tze-Fei Wong and Hong Xue (2003) 5,7-dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties. Biochemical Pharmacology. 66: 125-132
Wai Chung Leung, Michael Huen, Sek Lun Law, Hui Zheng, Hong Xue (2003) Anxiolytic-like action of orally administered dl-tetrahydropalmatine in elevated plus-maze. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 27 (56): 775-779
Michael S.Y. Huen, Hong Yan Wang, Kwok Min Hui, Justin W.C. Leung, Erwin Sigel, Roland Baur, J. Tze Fei Wong and Hong Xue (2003) Naturally occurring 2’hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands. Biochemical Pharmacology 66:2397-2407
Hongyan Wang, Kwok-Min Hui, Yingjie Chen, Suixu Xu, J. Tze-Fei Wong, Hong Xue (2002) Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis,binding to benzodiazepine site of GABAA receptor complex. Planta Medica 68: 1059-1062
Hui, Kwok Min, Michael S.Y. Huen, Hong Yan Wang, Hui Zheng, Erwin Sigel, Roland Baur, Hong Ren, Zhi Wang Li, J. Tze-Fei Wong and Hong Xue (2002) Anxiolyic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. Biochemical Pharmacology 64 (9): 1415-1424
Hui, KM, XH Wang and H Xue (2000) Interaction of flavones from the roots of Scutellaria baicalensis with benzodiazepine site. Planta Medica 66(1): 91-3
分子进化
Hong Xue and J. Tze-Fei Wong (2017) Future of the genetic code. Life 7(1), 10 (doi: 10.3390/life7010010)
J. Tze-Fei Wong, Siu-Kin Ng, Wai-Kin Mat, Taobo Hu, Hong Xue (2016) Coevolution theory of the genetic code at age forty: pathway to translation and synthetic life.Life 6 (1): 1-38
Wong, J. Tze-Fei, Jianhuan Chen, Wai-Kin Mat, Siu-Kin Ng and H. Xue (2007) Polyphasic evidence for the delineation of the root of life and roots of biological domains. Gene 403:39-52
Shui-Ying Tsang, Siu-Kin Ng, Zhiwen Xu and Hong Xue (2007) The evolution of GABAA receptor-like genes. Molecular Biology and Evolution 24:599-610
Xue, Hong, Siu-Kin Ng, Kalok Tong, J. Tze-fei Wong (2005) Congruence of evidence for a Methanopyrus-proximal root of life based on tRNA and aminoacyl-tRNA synthetase genes. Gene360:120-130
Xue, Hong, Ka-Lok Tong, Christian Marck, Henri Grosjean and J. Tze-Fei Wong (2003) Transfer RNA paralogs: evidence for genetic code-amino acid biosynthesis coevolution and an archaeal root of life. Gene 310: 59-66
Xue, H (1998) Identification of major phylogenetic branches of inhibitory ligand gated channel receptors. J. Molecular Evolution 47:323-333
Smith, DK and H Xue (1997) Sequence profiles of immunoglobulin and immunoglobulin-like domains. J. Molecular Biology 274:530-545
Xue, H and JT Wong (1995) Interferon induction of human tryptophanyl-tRNA synthetase safeguards the synthesis of tryptophan-rich immune system proteins: a hypothesis. Gene 165:335-339
Xue, H, WY Shen, R Giege and JT Wong (1993) Identity elements of Bacillus subtilis tRNATrp: Identification and evolutionary conservation. J. Biological Chemistry268:9316-9322
受体蛋白结构
Zhiwen Xu, Shisong Fang, Haifeng Shi, Hoiming Li, Jiun-Ming Wu, Hueih-Min Chen, Yiqun Deng, Yinglei Liao, Hui Zheng, Huaimin Zhu, Shui Ying Tsang and Hong Xue (2005) Topology characterization of a benzodiazepine-binding -rich domain of the GABAA receptor 1 subunit. Protein Science 14: 2622 – 2637
Haifeng Shi, Shui Ying Tsang, Man Kit Tse, Zhiwen Xu and Hong Xue (2003) Recombinant extracellular domain of the three major subunits of GABAA receptor show comparable secondary structure and benzodiazepine binding properties. Protein Science12(11):2642-2646
Haifeng Shi, Shui Ying Tsang, Hui Zheng, James N. Sturgis and Hong Xue (2002) Two -rich structural domains in GABAA receptor α1 subunit with different physical properties: evidence for multi-domain nature of the receptor. Protein Science 11 (8): 2052-2058
Xue, Hong, Haifeng Shi, Shui Ying Tsang, Hui Zheng, Christos G. Savva, Jingchuan Sun and Andreas Holzenburg (2001) A recombinant glycine receptor fragment forms homo-oligomers distinct from its GABAA counterpart. J. Molecular Biology 312(5): 915-920
Jun Hang, Haifeng Shi, Dongyang Li, Yinglei Liao, Dejun Lian, Yazhong Xiao, andHong Xue (2000) Ligand binding and structural properties of segments of GABAA receptor α1 subunit overexpressed in Escherichia coli. J. Biological Chemistry 275(25): 18818-18823
Xue, H, H Zheng, HM Li, A Kitmitto, H Zhu, P Lee and A Holzenburg (2000) A fragment of recombinant GABAA receptor α1 subunit forming rosette-like homo-oligomers. J. Molecular Biology 296 (3): 739-742
Xue, H, J Hang, R Chu, Y Xiao, H Li, P Lee, and H Zheng (1999) Delineation of a membrane-proximal β-rich domain in GABAA receptor by progressive deletions. J. Molecular Biology 285(1):55-61
Xue, H, RA Chu, J Hang, P Lee and H Zheng (1998) Fragment of GABAA receptor containing key ligand-binding residues overexpressed in Escherichia coli. Protein Science.7:216-219
联系方式：
邮箱：hxue@ust.hk